Annesse are you explaining the MS disease process to us in relationship to the (you say) missing Panc, Enzymes?? Even if you prove that theses missing enzymes definately lead to the cause of MS, Which I doubt you will, what causes these enzymes to deplete in the first place and how do we stop it?

Is MS causing the PEs to deplete or is the depletion causing the MS. Tricky little thing, huh? And this is why we haven't and probably never will find a cure.

Hey Sally~I think the evidence will show it is the depletion of these enzymes that leads to autoimmune disease. For instance, here is a study on the development of RA and lupus after exposure to insecticides. Insecticides are poisons. The very dictionary definition of a poison is that it kills enzymes.

RA and Lupus with increased exposure to insecticides. Spraying for
bugs could increase autoimmune disease risk – Press Release
Latimer, E. 2009. American College of Rheumatology.

The following abstract shows the association between the first outbreak
of chronic fatigue syndrome and fluoride in the drinking water. As the abstract confirms,
fluoride is a potent enzyme poison due to its affinity towards trace minerals.
From the Abstract Chronic Fatigue, Fluoride and Heavy Metals
Phelps, J.E. 2005.
Latimer, E. 2009. American College of Rheumatology.

The top 3 drugs that are known to induce lupus are all "enzyme blockers." Here is some information from my book.

Q: Why do some drugs cause lupus?
A: Certain medications may cause lupus. This is called drug-induced lupus. There are
38 known medications that can cause drug-induced lupus. Most cases, however, are
associated with procainamide (Pronesty), hydralazine (Apresoline), and quinidine
(Quinaglute). All three of these drugs are enzyme inhibitors.

We will be demonstrating "cause and effect" throughout this entire process. For instance, it is low levels of uric acid that lead to gout, not the other way around.

As the previous study showed( "Autonomic Dysfunction in Multiple Sclerosis: Correlation with Disease-Related Parameters" post #46) 90% of MS patients have autonomic dysfunction or dysautonomia. One of the neurotransmitters that regulates the autonomic nervous system (adrenaline) is derived from phenylalanine, which studies show MS patients lack. Phenylalanine is an essential amino acid that is derived from high protein foods. Protease break down high protein foods and release essential amino acids.

What is dysautonomia? Dysautonomia is a dysfunction of the autonomic
nervous system.The autonomic nervous system
is the part of the nervous system that supplies the internal organs, including
the blood vessels, stomach, intestine, liver, kidneys, bladder, genitals, lungs,
pupils, and muscles of the eye, heart, and sweat, salivary, and digestive
glands. The autonomic nervous system controls blood pressure, heart and
breathing rates, body temperature, digestion, metabolism (thus affecting
body weight), the balance of water and electrolytes (such as sodium and
calcium), the production of body fluids (saliva, sweat, and tears), urination,
defecation, sexual response, and other processes.

A dysfunction in the autonomic nervous system (dysautonomia) can cause
dizziness or light-headedness due to excessive decrease in blood pressure
when a person stands (orthostatic hypotension). People may sweat less or
not at all and thus become intolerant of heat. The eyes and mouth may
become dry. After eating, a person with dysautonomia may feel prematurely
full or even vomit because the stomach empties very slowly (gastroparesis)
Some people pass urine involuntarily (urinary incontinence), often because
the bladder is overactive. Other people have difficulty emptying the bladder
(urine retention) because the bladder is underactive. Constipation may
occur, or control of bowel movements may be lost. The pupils may not
dilate and narrow (constrict) as light changes.

A dysfunction in the autonomic nervous system would explain why
MS patients are prone to bladder infections and other types of bladder
dysfunction. “Bladder dysfunction occurs in at least 80% of people with
MS. Some estimate that up to 96% of people with MS who have had MS
for more than 10 years will experience urinary problems at some point,”
states Julie Stachowiak, Ph.D.

Autonomic nervous system dysfunction would cause the nerves of the
bladder to not respond normally to pressure as the bladder fills with urine.
This would result in urine staying in the bladder, and leading to an increased
risk of urinary tract infections.

Phenylalanine is also needed to produce both of the thyroid hormones,
so we would expect MS patients to have an increased risk of developing hypothyroidism. The following study on MS and thyroid disorders found
that thyroid disorders were at least three times more common in women
with MS than in female controls, and that, this was accounted for mainly
by the prevalence of hypothyroidism.

Association of MS with Thyroid Disorders.
Karni, A., O. Abramsky. 1999. Neurology 53(4):883-5.

I agree that poisonous chemicals could cause MS. A few years ago there was a study posted here (very extensive study) saying that MS could be from more than one cause, i.e. two of these being auto-immune disease and chemical effects. This has not been studied enough, though. Or if studied, the information doesn't get out there where we see it often.

Anyway, no info from you, Annesse, on what to do. In Porphyria our main defense is avoidance. Avoid triggers of all kinds as much as possible--pesticides, herbicides, some foods, many drugs, composite furniture, new rug, rug cleaner, formalin in new clothes, on and on.

This is the wording of the full abstract above:
from http://www.ncbi.nlm.nih.gov/pubmed/10489063

Hint:
When you cannot post a link (being new etc here), to a PubMed article, you CAN give its PMID # to make it easier for others to find that abstract. Just give the title, and the PubMed PMID #
which in this case is 10489063. Then the reader can just plug in the PMID # into PubMed search engine and find it more quickly that way. No link needed, and we have a hyperlink on each page here to PubMed for convenience anyway.

We are looking for some answers, not more questions Annesse. We already know that just about anything and everything can trigger MS, but WHAT do we do about it???

Thanks..

I've got more questions. I'm interested in relationship between MS and:

-Uric Acid
-Neopterin (It has a relationship in AIDS and as a marker for Immune System- Cytokines and Interferon-gamma)
-Albumin
-Atlas Orthogonal in neck and CNS fluid.

No wonder MS remains a mystery. I'm out of my depth, nap-time. I just have very vague understanding of this stuff. I always tell my Johns Hopkins MS specialty Neurologist to call me when MS is cured. He laughs. But I know he would call me.


(Us MSers sure know a lot-regular peeps don't look at this stuff!)

How about Globulins...is there any relationship to MS???

Thanks

Annesse,

Question: When are these enzymes missing? At birth or older?