RW, good one !

Thanks to all for the feedback. LL has been prescribed valium for spasticity - mostly muscle cramping. The joint pain is intermittent. She has good days without any joint pain at all - then she might have a week of severe joint pain without relief.

The valium doesn't seem to have any effect on relieving the joint pain although it does help with occasional muscle spasms. I suspect that the joint pain is a MS systemic symptom and not a side effect of Tysabri since this symptom manifests itself regardless of her medication regime with valium and seems to have no direct correlation with Tysabri infusions.

RW, have you ever used valium for spasticity? Are baclofen and tizanidine comparatively more effective? This joint pain issue is really impacting our quality of life. As you described it, LL also has days where she feels like she has been hit by a car and can't get out of bed.

Appreciate your feedback.

JJ