I went into detail in your PM about the WBC and the BBB Natalie.

NSF is a disease that has been noted in some folks with kidney problems after use of gadolinium. You may see some commercials on TV from ambulance chaser lawyers about this. Evidently a lot of MRI companies are now testing for kidney problems before using gad now. I think the testing is like shutting the barn door after the fact for those of us who have had numerous MRIs with contrast.

The Remeron, cyproheptadine and mefloquine are very inexpensive antivirals or in the case of Remeron, used to treat depression but has anti viral qualities.

The BBB is supposed to be impermeable. Rogue T cells and WBCs are what gets by when the BBB loses that impermeability. Tysabri acts to block the T cells and the WBCs from crossing the BBB, restoring the BBB to impermeability. WBCs are the signal that there is inflammation. The body sends them out to fight it. That's why lesions are created, the WBCs are fighting the rogue T cell damage. We don't know why those T cells go rogue or why they are able to get into the brain or why the BBB opens. Tysabri doesn't block them all but it stops a lot of them. That is why some people still have relapses and lesions. There is still damage going on in many cases.

I am looking forward to seeing my new MRI when it's done. I had a really good one at 6 months. I am hoping that after 20 infusions I see more improvement. My last one showed no new lesions, no enhancing lesions and many of the large lesions were gone or greatly reduced in size.

I haven't had a relapse since I started and that for me, is the greatest benefit! I was cycling through every three months or so and to be able to see straight and clear, to be able to walk in a straight line without balance problems and dizziness, to be able to do most of what I did before MS is truly a benefit. It may not be a cure, but it works for me.

(now if I could only get rid of the spasticity and stiffness...That damage is IMO, directly related to NOT being able to have Tysabri when it was off the market, causing damage that has not repaired. I still have hope for that problem, when I look at the data on famipridine (4-AP))