I know exactly how you feel. This is the pre-cursor to an exacerbation for me! You might want to call your doc and see if you can get in for an office visit.

Are you on any anti-fatigue meds? Provigil, amantadine, ritalin, adderall?

You might want to make sure you don't have a bladder or yeast infection, or any other kind of infection as well. Any kind of infection can cause that fatigue feeling. I've just gone through over a month of a horrendous sinus infection and all I've wanted to do is sleep...but haven't been able to. I've had what the neuro called an infection triggered exacerbation. Not treatable by steroids, just high dose antibiotics. I am feeling a lot better, but still dealing with a lot of fatigue. I am taking 400mg of Provigil a day.

I hope you get better soon, but if it were me, I would call my doc.