I'm so very sorry to hear about your reactions sassy.

I had something similar with Copaxone. I then got site reactions so bad that not only did I have a painful red tummy, but I developed blisters as big as golf balls (full of luid) hanging from every available bit of skin on my abdomen.

I then proceeded to fit. Needless to say, I don't take Copaxone any more, and as I reacted to Interferon as well, I don't take any of the DMDs.

I recently had most of my nose removed, and then rebuilt, because of an infiltrating basal cell carcinoma . I know that's not the same as a melanoma, but I have a feeling that with my history of the skin cancer as well as drug reactions, most neuros would be reluctant to order me Tysabri.

I do hope I didn't worry you with my own reactions. I think I must be weird when it comes to medications, as few people seem have to sort of drug reactions that I get.

I wish you the best of luck tomorrow.

Like Girlie Girl, I went from A to R. No depression on either for me.

If it were me, I wouldn't try A. Bottom line is that A and R are the same type of interferon. If R induced severe depression, I would think that A would cause it too.

I hope the doc can give you some good answers/ideas.

Dang, Sassy, still? That's too bad, but I'm glad they told you to stop. When my doc took me off B after a wild depression, she said that I'm officially one of the "no interferons b" ever again club. That's when I went on C.

As you know, I've been off all DMDs since last July and have not noticed any changes (remember, I was promoted to SP last year).

We did talk about TY, but I'm not so sure about that one. LDN might be a viable option but I'm kind of in a holding pattern to see how I do. I honestly don't see a difference.

I hope you'll find the next best thing for you. Keep us posted.

Sassy, it's different for everyone. Jim originally took Beta, then Copax, then Avonex. He is now back to Beta and does just fine on it. Avonex just about wiped him out every shot. He would be down for days with fevers. Copax just didn't seem to be working. On Beta he has leg cramps the next day but nothing Ibuprofen can't handle. The only draw back is remembering to take a shot every other day. His neuro refuses to put him on any of the newer drugs since his reaction to Avonex was so rough. BUT, with that being said, after taking Avonex he only had one active lesion. So, in our opinion it was working and doing it's job. We are hoping for the same outcome with Beta since he tolerates it the best.

Cindy brought up a good point. Jim has experienced depression with Beta. He's now on Zoloft and doing fine.

Sassy, sorry to hear you had so many IPIRs. Hope you and the neuro can find a med that agrees with you.

Thanks guys! A couple more hours to go 'til my appt.

Cindy, I remember when I went off Rebif my neuro said no more interferons. So, I plan to remind her of that and see what might have changed her mind.

Cheryl, the melanoma was a scary, scary time for me and I don't know if I can go through the worry. I am going to ask my neuro what she has heard about the melanoma risk with Tysabri.

My mind is thinking a hiatus from everything might just be nice.

Good luck my sassy friend. Let us know what the doc says

I'm sorry to hear about your problem with Copaxone Sassy! Darn it anyway!

If you decide on an interferon, you'll probably for sure need to take an antidepressant if you don't already. I didn't start on one until I started taking Rebif but I should have taken one sooner I think.

I felt better on Avonex than I did on Rebif myself. When I switched to the higher dose of Rebif my depression got a lot worse.

Good luck with whatever choose!