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Old 06-19-2008, 01:04 PM #1
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Default 1000 IU Vit D3 positive effects for MSers

Here is one study done at Penn Stata Univ funded by the National Multiple Sclerosis Foundation which back in 2001 showed how Vit D3 supplements can help blood chemistry. This is from their public press release at that time.

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Study points to positive results from vitamin D supplements for MS sufferers
University Park, Pa. --- A small study conducted by researchers at Penn State
and Helen Hayes Hospital in New York has shown that a daily dose of vitamin D –
1000 IU or two and a half times the recommended dose for adults -- causes
changes in blood chemistry that indicate positive effects for multiple sclerosis
patients
.

Dr. Margherita Cantorna, assistant professor of nutrition, says the study has
not been in progress long enough to observe changes in the clinical symptoms of
the disease in the patients who participated. However, blood samples drawn after
just 6 months of Vitamin D supplementation, show an increase in transforming
growth factor beta-1 (TGF-Beta) which is associated with the remission and
suppression of the immune response which produces symptoms in MS patients. In
addition, the researchers found a decrease in interleuken-2 which is associated
with the cells that induce MS.

Cantorna's student, Brett Mahon, a doctoral candidate in nutrition, detailed the
study results today (April 3) at the Experimental Biology 2001 conference in
Orlando, Fla. The paper, "Altered Cytokine Profile in Patients with Multiple
Sclerosis Following Vitamin D Supplementation," is co-authored by Dr. Felicia
Cosman, medical director, Clinical Research Center, S. A. Gordon and J. Cruz,
all of Helen Hayes Hospital, and Cantorna. Mahon is first author.

As a postdoctoral fellow at the University of Wisconsin, Madison, Cantorna and
others had shown, in experiments with mice, that vitamin D supplementation could
completely prevent the development of MS in susceptible animals. After Cantorna
joined the faculty at Penn State, she learned of Dr. Cosman's research program
which centers on investigating whether a low level vitamin D deficiency in MS
patients might account for the incidence of brittle bones.

Cantorna asked Cosman for blood samples from the participating patients to see
if the same changes she had observed in mice also occur in humans who receive
vitamin D supplementation. She found that the results were, in fact, similar at
the blood chemistry level. Multiple sclerosis is an autoimmune disease in which
the victim's own immune system attacks the spinal cord and brain. The disease
afflicts about 350,000 people in the United States alone and its cause is
thought to be a complex interaction of genetics and environmental forces that
are not completely understood.

Cantorna and others hypothesize that one crucial environmental factor involved
in the development of the disease is the amount of sunlight a person receives.
Exposure to sunlight catalyzes the production of vitamin D in the skin. In low
sunlight, the skin produces significantly less vitamin D.

In support of a connection among sunlight, vitamin D and multiple sclerosis,
Cantorna points out that the incidence of the disease is nearly zero near the
equator and increases with latitude in both hemispheres. In addition,
Switzerland has high MS rates at low altitudes and low MS rates at high
altitudes. Ultraviolet light is more intense at higher altitudes, resulting in
the skin manufacturing more vitamin D.

Other evidence of an MS/vitamin D link comes from Norway where MS rates are
higher inland than on the coast where larger quantities of fish are consumed
which are rich in vitamin D.

While Cantorna's research and MS's geographical distribution suggest a
connection between vitamin D and MS, she cautions that the vitamin's exact role
is still unclear.

"I think that if you are an MS patient, it would be best to continue to follow
your personal physician's advice," says the College of Health and Human
Development faculty member. Since vitamin D can be toxic in high doses, it would
not be a good idea to begin taking vitamin D pills available over-the-counter in
large amounts.

"On the other hand, since adequate amounts of vitamin D are difficult to get
from diet and because MS patients often have to stay out of the sun, you might
want to consider taking a vitamin D supplement at the current recommended daily
requirement level. There are potential benefits for bone health and for the
immune system as well."

The project was supported by two grants from the National Multiple Sclerosis
Foundation -- one to Cantorna and the other to Cosman.

Last edited by Chemar; 06-20-2008 at 04:38 PM. Reason: adding correct quote tags
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Old 06-19-2008, 03:43 PM #2
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Thank you for these studies. It is not easy to find nutrition research that relates to MS.

It is predicted that the minimum requirement for Vitamin D will be increased in 2010, when the decade cycle on nutrition updates is scheduled.

Anytime a nutritional requirement is changed it affects food programs, such as food stamps, WIC, and school lunches to name a few. They try not to change them too frequently.
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Old 06-19-2008, 06:25 PM #3
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There was a news story on vitamin D and MS on the news tonight. It dealt with a study that examined twins and preventing MS. You can read it on their web site. Just click on the health search engine.
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Old 06-19-2008, 09:44 PM #4
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Being cognitively challenged at times, that was quite a bit of information to absorb so bear with me if this was in Jack's post. In order to get an adequate amount of D3 one must get an adequate amount of sunlight with ultraviolet B. This is challenging for some in many parts of the country. Not so for the southwestern states. When the weather is cooler, I sit out in the sun for 15 minutes a day give or take. When it is hot, as in now, I will sit by a window. Would sitting by the window be enough?

BTW - I lived most my life on Long Island and CT. Additionally, I know of 4 people that were born and raised in AZ that have MS. So I am not 100% convinced on the vitamin D theory.
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Old 06-19-2008, 09:52 PM #5
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There is also a good thread on Vitamin D in the vitamin forum.

also I remember an article where they did a test on people in Hawaii (sunny all the time right) and there was a good proportion that had low vitamin D.

So there are people that either do not absorbe well through the sun or dont convert well was what I think it said.

My Vit D was low and I have been supplementing with 1000 iu a day and it has definitely helped with muscle pain and fatigue.
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Old 06-19-2008, 10:25 PM #6
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In Rod we trust Go Blue !!! love it Shelley.Well, I sure hope my Vit D levels will be normal in 8 weeks when my neuro will do another blood test to check my levels again,I wonder if she'll want me to stay on Vit D I don't know because I want to stay on it as it sounds like it really can help me.

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Old 06-20-2008, 03:37 PM #7
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FYI: I had posted this in another forum last month.

There is a great article on Vitamin D starting on page 44 of this month's Cooking Light magazine. It predicts that when the new levels get reset in 2010, they will be increased. ( They only reset nutrition level every 10 years.)

"In the absence of it,"... (vitamin D) ..." you're asking the body to defend itself with one hand tied behind its back."

I was surprised b/c it said that a fair skinned person manufactures as much as 15,000 IU in 30 minutes with optimal sunlight conditions, so that is why they think giving people 10,000 IU as a supplement is okay!

The normal values for daily intake are 200 to 400 IU according to your age, but this information is a decade old.

It gives guidelines on the time of day for the sun to be at a 45 degree angle above the horizon and speaks about those of us who live above the 35 degree of latittude ( North Carolina to Southern California).

An spf of just 8 will block 98 percent of your skin's vitamin D production. So we should not have it on all the time.

They suggest having Vitamin D levels checked with bloodwork for something that insurance usually covers like a cholesterol panel or any other annual test. However they think you should always check with your insurance company first.

Most public libraries have Cooking Light magazine in the periodical area.
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Old 06-20-2008, 03:43 PM #8
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Quote:
Originally Posted by Kristi View Post
In Rod we trust Go Blue !!! love it Shelley.Well, I sure hope my Vit D levels will be normal in 8 weeks when my neuro will do another blood test to check my levels again,I wonder if she'll want me to stay on Vit D I don't know because I want to stay on it as it sounds like it really can help me.

Go Blue !!!!!
Yep Kristi,

Counting down to the start of the season.

If I were you after the 8 weeks I would go on a maintainence dose of like 1000iu a day of D3. Otherwise over time it will just deplete again.
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Old 06-26-2008, 05:51 PM #9
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Default vitamin D3

I asked my doc to check my levels and they were excessively low. She put me on the mega dose for awhile and now I take 1000IU a day to maintain. I don't feel any different, but I do believe no one should have low levels of anything without paying consequences later on.
I grew up in Michigan so enough said.
Perhaps people with low vit D levels get sick....or maybe sick people develope low levels of vit D.....I'm not sure...but getting your levels up is optimal.
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Old 06-26-2008, 07:41 PM #10
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Hi jackD. I checked my calcium, Vitamin D and K supplement pill and it is vitamin K1 that I have in this pill, 40 micrograms, and I take 3 a day at each meal.

The daily suggested amount of Vitamin K is 120mcg. So that level is okay for me.

http://en.wikipedia.org/wiki/Vitamin_K

I was wondering about K2 and I found out from this article that we make in our large intestines. I knew we made it, I just didn't know whidh form. It also talks about calcification of the artieries as you mentioned, b/c of a lack of vitamin K.

This form of vitamin k is also available in some foods.

I am going to have to take some notes about the other things you cite and look into them, too.
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