I have an exacerbation in August, had my last vaccine on Sept 21. Other than that, I did fairly well from the time I started the shots in March until the exacerbation in August and it was a pretty bad one. I was down, and I mean down, for almost a month. Then I got that horrible sinus infection mid-December that after 2 rounds of antibiotics turned into a staph infection in my right sinus cavity.

Then another flare in April.

The months that I was on the vaccine, I'd say I was pretty stable...fewer complaints other than the fatigue. I had to increase the provigil and then after the August flare, I got steadily worse. Fatigue and pain.

No colds or viruses that I can remember during the vaccine period. Just after I stopped in September and since. I've had 2 exacerbations since I stopped...one was infection induced (sinus infection) and the other was a regular old exacerbation (April).

To answer your question about worse during or after? Definitely after. Back to the pre-trial me...only a bit worse...pain level is higher and definitely the fatigue level is higher. 400 mg of provigil does nothing. I take it and then I crash in the afternoon. So I am now just taking 200 so I don't have that afternoon crash. That's has been horrible.

Doc put me back on Sinemet for the spasticity. Added that to the Soma, along with Klonopin. Norco and/or Vicodin as needed. Seems to be a good cocktail as I have to function during the day. Sinemet doesn't make me drowsy. The Soma and Klonopin do. I found out that 1.5mg of Klonopin is 3 times the normal dose!! Ms. drug lightweight is maxed out on that one and it's not touching the RLS...Requip did nothing...

Long answer to a short question...