Yes, many men and small/tiny women (around 100 lbs) can not tolerate more then 3.0 mg, and others with spasticity problems sometimes can't either. For some of us the spasticity is just a transitory initial side-effect, or occurs only during cold "weather", etc, so it may require some trial and error/flexibility to find out what works best for us as individuals.

I couldn't get up to 4.5 mg for about 6 months, and have to drop down for a few weeks every Fall when the colder weather hits . . . however for the rest of the year I am fine at 4.5mg.

3.0 mg is the "ideal" dosage and sufficient for many of us (according to Dr B), so I wouldn't be too concerned with forcing the 4.5 mg dosage level. We are still "protected" at 3.0mg . . . it's just that some of us are determined (for no particular reason :rolleyes:) to keep trying to get to 4.5 mg. That dosage may CAUSE problems for some, or IMPROVE symptoms for others . . . so it's a matter of finding what works best.

You are welcome, Mom2Five.

Cherie

Actually, I was in KY. I will have to look into that.

This makes sense to me...thanks! ;)

Where can I find a copy of this publication?

I got that quote from Sammy's website:

If you click on the various links on that site, you will find most of the recent trial results. That trial was very short, and it included people on all the various CRABs, so I didn’t expect it to have amazing results . . . although it does seem there were some.

The recent trial that I am most impressed with is this one:

http://neurotalk.psychcentral.com/sh...ose+naltrexone

The link I have in my first posting (of the above link) shows that it was published in Pubmed, which is very impressive to doctors.

Cherie

LDN stands for, Living Darn Nice..:D (Under the circumstances)

I don't know if the stuff is doing anything.......all I know is that I Feel Better than I did on those shots.

I hope everyone is doing as well and feeling as well..:grouphug:

I have a message in to get a consultation today...I'm hoping for the Rx soon. I didn't do my Avonex yesterday and feel a little bit better today. I appreciate the encouragement and the help. :Tip-Hat:

Hi My name is Jnet this is my first time posting on this site. I just started LDN 11/1/08. I'm taking 1.75 one night and 3.5 the next. We want to slowly bring my immune system up. then pretty soon 3.5 for a month. then we will try 4.5. When I do the 3.5 I feel more enerergy. I feel a little bit better balance but not a lot yet. I am excited. I quit Tysabri in September. :)

Welcome to Neuroalk, Jnet and to our little LDN thread..So nice ro meet you..:) .. That's a strange doseage combo you are on, but whatever works for you, is okie dokie with me..:D

I'm happy to hear it seems to be helping you, so far and I hope is continues to do so and even improve over time.

So sorry the Ty didn't work for you.

Let's hear more from you and again, Welcome..:hug:

Welcome jnet! I'm new too. Everyone is soooo helpful. Be sure to let us know how you are doing. We're in this together! ;)