curious about something if I may ask a few of you same question, how long after taking the LDN did you start to notice a change, at the present time i stopped the other meds first and my spasm and muscle spasicicity was starting to build, being off the other meds yet now i am noticing they are not as sore this past two days or so the spasm in my neck are not as often, and i got energy, now here is my dilemma was it the other meds making me tired or LDn making me less tired, could side effects from other meds mess with my muscles or is LDN working i am so confused ok more so than normally

Yes, It's the LDN..

I noticed the difference, the first day....I thought it was just placibo, but it lasted. Apparently the small dose is working on you...I'm surprised, but delighted.

The energy and lack of Fatigueness is due to the small increase in indorphins, I think. PwMS are usually very low in indorphins.

Keep up the good work, Franky .

Frank, I'm confewzed too!

I actually felt a degree worse the first week.

It messed with my sleep a few nights and I had some disturbing dreams.

No cramps (have never had them). Minor dull headaches occasionally. Some achyness, but don't know if it's the LDN or just me!

I've been kinda crabby lately, but again, could just be me (don't ask DH, Lol!) Temporary numbness in new places.

I guess I'm really not any worse off than before LDN, so I'm planning on sticking with it.

Good luck Frank, et al! Nice to have a support group here on NT!

yes it is to have support on here Twink, I also had a few sleepless nights when i started it. like i said i have noticed a couple of slight changes, just going to keep on keepin on and see what comes of it

thank you Sally for this thread

Did you make any other med changes at the same time Twinkletoes?

I had some side-effects too, for the first few weeks. Are you drinking a full glass of water after each dosage . . . that was the step I was missing?

Some people take a little longer to adjust, apparently especially if their damage is a little older (2+ yrs). Let us know how you are going by the third week . . . it should all settle down by then.

Cherie

Sorry Twink...I had vivid dreams too...still do, somewhat. Your doing well to hang in there. Since you are on such a small dose, perhaps some of your others meds are working harder in your system than the LDN???

Thanks Cherie, Sally and Frank.

I didn't know I was supposed to drink a full glass of water with my capsule????

I'll do that tonight for sure.

Nope, I didn't make any other drug changes.

I picked up that tip somewhere, and added into my "risk assessment" document for my doc, but then promptly forgot. After a couple of weeks of nausea, I re-read the instructions and saw to take it with water. Never had a problem after that night.

I take liquid (although the instructions were for any LDN), and I think it made a difference especially for that method. It might not make any difference for the capsule, even though they recommend it.

I forgot to mention throughout this thread (although Sally may have) that LDN only stays in our system for about 18 hrs, so if we ever have to go off for any reason, we are "clean" by the next day. This is also the reason that symptoms that LDN helps for, will start creeping back within a few days.

Also, did any of us mention to take the LDN after 9:00 pm (or is it 11:00, Sally?), cause it works with our sleep patterns? Most people who've done the research know not to take it till late already (and I take it after midnight, as a habit), but for those who may have forgotten . . .

Cherie

I noticed a BIG difference in my spasticity pain almost immediately (within a few days), but I was on 3.0 mg from the beginning too. I had suffered with that pain, to the point that I had to wear braces on my limbs every night and many days, for almost 2 yrs. I have only had to use one brace, once, since I started on LDN.

It could be either thing that's helping you, Frank; going off other meds OR going on LDN. I waited several months to try weaning off Celexa because I wanted to know which drug was helping/hurting. Ultimately, I knew it was LDN that helped with certain things, and Celexa that caused me other side-effects.

After you've stabilized at 3.0mg or 4.5mg, you can try stopping it for a few days to see.

Cherie