"The introductory dose is just 3 mg for the first month of treatment. It has been reported that those receiving this drug in the treatment of MS experience a range of benefits, including reduced spasm and fatigue, and improvements in bladder control, heat-tolerance, mobility, sleep, pain, tremor and others. After this period (in the absence of any introductory side effects), and for greater therapeutic response, the dose can be increased to the current maximum recommended dose of 4.5 mg per day, to be taken between 9 at night and 3 in the morning.

For those unable to tolerate even the 3 mg dose, lower doses of 1 or 2 mg are available. Such doses are intended to introduce the therapy more slowly, allowing more time for the necessary endorphin response to develop."

http://www.ldnresearchtrust.org/default.asp?page_id=77

"What dosage and frequency should my physician prescribe?

The usual adult dosage is 4.5mg taken once daily at night. Because of the rhythms of the body's production of master hormones, LDN is best taken between 9pm and 3am. Most patients take it at bedtime.

Notable exceptions:

People who have multiple sclerosis that has led to muscle spasms are advised to use only 3mg daily and to maintain that dosage.

For intial dosage of LDN in those patients who have Hashimoto’s thyroiditis with hypothyroidism and who are taking thyroid hormone replacement medication, please read Cautionary Warnings, below.

Rarely, the naltrexone may need to be purchased as a solution — in distilled water — with 1mg per ml dispensed with a 5ml medicine dropper. If LDN is used in a liquid form, it is important to keep it refrigerated.

The therapeutic dosage range for LDN is from 1.75mg to 4.5mg every night. Dosages below this range are likely to have no effect at all, and dosages above this range are likely to block endorphins for too long a period of time and interfere with its effectiveness."

http://www.lowdosenaltrexone.org/#Wh..._and_frequency

.... so, I guess there isn't a straight answer out there.

Cherie