This is what I've heard through the NMSS-We have received a number of inquiries about the use of low dose naltrexone (LDN) as a treatment for multiple sclerosis. There are currently no published data from controlled clinical trials to support the use of naltrexone in MS. Further study is needed to determine if this is a safe and effective treatment for people with MS. This was in 6/08. All the other "negative" stuff have been in other MS magazines or MS books that I have. I also have heard the positive things. I'm going to talk to my neuro about in January. If she won't prescribe-any suggestions.