Wanted to clarify that I don't think flavoring has anything to do with the speed of release of the drug, just that apparently it does make some difference for efficacy. Both times that I tried other flavoring (banana and bubble gum, if I remember correctly), my symptoms were creeping back in. As soon as he got the right flavoring in, he replaced my rx with the Tootie Fruity/Raspberry, no charge.

I didn't try any other meds before LDN either, but I was 14+ yrs into the disease before I tried anything (not even steroids). There were several reasons I went that route:

- my neuro said the CRABs weren't likely to help my "type" of MS (mostly large spinal lesions, very few brain one's even that long into the disease)
- sensitivities/allergies to meds
- CRAB efficacy stats were not convincing to me
- report side-effects on the CRABs
- cost
- anecdotal evidence on LDN

I won't ever regret not trying anything else, but that is because I have been lucky that LDN has worked as well as I could hope for with any med. I do understand why neuro's recommend the mainstream meds first though, and I probably would too if I were in their position. Actually, I'd probably recommend Copaxone and LDN first.

Cherie