[JoeMac]

Hi All,

I went for infusion #2 today and after a few UNsuccesful tries they FINALLY got a vein to use on me, they sugessted I get a port........Duh, that is what I wanted from the start......BUT after the whole dose of Ty went in I developed a slight red blotchyness on my arms and stomach.......they gave me IV benedryl and took a vile of blood from me to check for antibodies.

i would think that I should be OK for Tysabri in the future because it was such a slight reaction BUT the blood work will tell the story on if I stay on it or not..

This is IT for me as far a the CRAB drugs go, I have tried them all, ty is my one last hope........

Has anyone else had this problem?

Thanks

Joe

[Riverwild]

Hi Joe!
Sorry to hear about your rashy stuff! Your neuro may have you pretreat with Benadryl and tylenol before infusion now.

I have had pinpoint itching during infusion for awhile now. It doesn't get worse, there's no physical evidence, no further signs or symptoms involved. I am trying to get to the bottom of it during infusion. I noticed that the mixture in the IV bag seemed to be separating towards the end of infusion , so last month we rotated the bag a few times and no itchies.

Have you posted this on the Tysabri thread? Maybe you will get a response from someone who is now or has been on Ty and has had these symptoms.

I hope it works out for you! Please let us know how it comes out!

[tovaxin_lab_rat]

If the presence of persistent antibodies is suspected, antibody testing should be performed. Antibodies may be detected and confirmed with sequential serum antibody tests. Antibodies detected early in the treatment course (e.g., within the first 6 months) may be transient and disappear with continued dosing. Repeat testing at 3 months after the initial positive result is recommended in patients in whom antibodies are detected to confirm that antibodies are persistent. Prescribers should consider the overall benefits and risks of TYSABRIÒ in a patient with persistent antibodies.

http://www.tysabri.com/tysbProject/tysb.portal

I hope this explains the antibody stuff for you!

[Taffy]

I am sorry!

(I am so glad I was sitting down when I read your post by the way!)

[NurseNancy]

i'm sorry about the reaction joe.
i hope you can con't with the med.
but sometimes reactions will only get worse. i'm sure they'll let you know.

good luck.

[lady_express_44]

You aren't using Benadryl now, Joe? Many people do . . . although I don't necessarily agree. I always avoid allergens, personally.

I've heard of some that Benadryl does the trick, and others where the next reaction (after one like this) is much worse. PLEASE make sure someone stays with you next time, or there is a good emergency notification.

I hope you are one that can manage the allergy though, as I know you had high hopes for this treatment option.

Cherie