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-   -   Trouble sleeping (https://www.neurotalk.org/myasthenia-gravis/173604-trouble-sleeping.html)

BackwardPawn 08-12-2012 07:43 PM

Quote:

Originally Posted by alice md (Post 904924)
Neither will cancer, plague (and other severe infections).

In fact without modern medicine and its poisonous medications we would all live to be 100, staying young and healthy.

Without modern medicine there would be no diseases at all.

This guy you keep on citing is a fraud. He sells pseudoscience and illusions.
He uses half truths to convince you with very wrong conclusions.

Possibly (and hopefully) your MG is relatively mild and under good control without any medications. But, you are still at risk of having a more severe exacerbation which could endanger your life.

Please watch this movie of an MG patient, prior to there being any medical treatment for this illness. The mortality rate at the time of Marry Walker when patient with MG received no "acidic poisons" was very high.

http://www.youtube.com/watch?v=uRoRs...eature=related

Just curious, but if Prostigmine already existed when she did her experiments, what was it developed for?

Brennan068 08-12-2012 08:07 PM

Quote:

Originally Posted by BackwardPawn (Post 905265)
Just curious, but if Prostigmine already existed when she did her experiments, what was it developed for?

It was developed to defend against nerve gas attacks at the end of WWII, specifically "Soman".

http://www.infobarrel.com/What_is_Py...ine_Bromide%3F

MrGSH 08-12-2012 09:17 PM

Try Drinking Tart Montmorency Cherry Juice
 
I have found Tart montmorency cherry juice to be very helpful for helpin me sleep. You can find in most health stores. It should be unsweetened, no additives.
:hug:


Quote:

Originally Posted by MrsVgz (Post 899550)
I'm wondering what other MGer's out there do to truly get a good nights rest. I am currently on 20mg of hydroxyzine per night, yet, I don't wake up feeling rested. (I am sleeping 4-6 hours per night.) I've tried calming teas, epsom salt baths before bed, no eating, and other things. What are some of the things/medicines you all have found to be effective? I go back to my neuro on the 30th and would like to discuss other options. Any input would be wonderful. I've struggled with MG for 10 years now, and it only seems to be getting worse...not ready to just give in though. I need sleep...I need to wake up feeling refreshed. :/


alice md 08-13-2012 11:47 AM

Quote:

Originally Posted by BackwardPawn (Post 905265)
Just curious, but if Prostigmine already existed when she did her experiments, what was it developed for?

Curare was used by the Indians as a poison on their arrows.

It caused paralysis of the person hit by it.

This led to physiological studies in the 19th century. It was later used in surgeries to stop patients from moving (and its derivatives are still used for that purpose today).

physiostigmine is a natural substance produced by the calabar bean.

It was coincidentally found to reverse the effect of curare in anasthesized dogs. http://www.nickalls.org/****/papers/...urare1985a.pdf

Marry walker noticed that patients with myasthenia have symptoms resembling curare poisoning. That is why she tried physiostigmine.
But, this natural substance had significant side-effects.

The pharmaceutical company Roche developed a synthetic substance which was more tolerable-prostigmine. (later the name was changed to neostigmine and is still used by anasthesiologists to reverese muscle relaxation after surgery)

This was given to another MG patient with better results.

http://www.ncbi.nlm.nih.gov/pmc/arti...0680-0107b.pdf

Pyridostigmine was developed later as an oral medication. As was oral prostigmine and mytelase.

BackwardPawn 08-13-2012 10:30 PM

Quote:

Originally Posted by alice md (Post 905388)
Curare was used by the Indians as a poison on their arrows.

It caused paralysis of the person hit by it.

This led to physiological studies in the 19th century. It was later used in surgeries to stop patients from moving (and its derivatives are still used for that purpose today).

physiostigmine is a natural substance produced by the calabar bean.

It was coincidentally found to reverse the effect of curare in anasthesized dogs. http://www.nickalls.org/****/papers/...urare1985a.pdf

Marry walker noticed that patients with myasthenia have symptoms resembling curare poisoning. That is why she tried physiostigmine.
But, this natural substance had significant side-effects.

The pharmaceutical company Roche developed a synthetic substance which was more tolerable-prostigmine. (later the name was changed to neostigmine and is still used by anasthesiologists to reverese muscle relaxation after surgery)

This was given to another MG patient with better results.

http://www.ncbi.nlm.nih.gov/pmc/arti...0680-0107b.pdf

Pyridostigmine was developed later as an oral medication. As was oral prostigmine and mytelase.

Thanks. I find the history of all this very fascinating as nothing was developed specifically for MG, they just found other things that worked. Its a shame that they're limiting our choices now by taking the other two off the market.


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