[Tom5C]

I have been taking low dose naltrexone and one or the other of two calcium channel blockers for almost two years and have had no symptom progression in that time. Has anyone had a similar experience?

[RLSmi]

Tom5C, can you share your date of diagnosis with us and the nature and severity of your symptoms at that time? Was one of the calcium channel blockers Dynacirc? If so, what was the other?
Robert
ps I just read the answer to all of my questions on your other posting.
R

[jeanb]

Tom5C

I'm on Dynacirc - 2 years now - slowly progressing.

[ashleyk]

Hi Tom,
I have been on 4.5mg of naltrexone for 5years, 4 months. I won't say I have not progressed but my PD meds are still in the low range. I am tremor dominant I guess, no stiffness yet. Actually, I have cut back on Mirapex by half because of ankle swelling. My Sinemet 25/100 remains at 1.5 to 2 tabs a day. Also I have been taking Q10 up to 1200mg/day at the suggestion of my Neuro (she still doesn't know I take LDN). She now wants me to stop Mirapex and start Requip. But will Requip still cause ankle swelling? She also mentioned Azilect. These are two expensive drugs which the jury is still out on from what I've been reading.
As far as LDN is concerned, I base my hopes on it from the work that Dr. Hongs Pharmacology Group has done at the NIH.
http://www.fasebj.org/cgi/content/full/19/6/550
If one scrolls to the very bottom of the paper, they show journals that publish reports on naloxone (LDN), DXM etc. Most of the older pubs are free to read.

[chasmo]

All of you are well within the "symptom progression" window. my last one was 4.5 years in duration. So I do not think that your med protocol has anything to do with it. The placebo effect could be at work.

Of course I could be full of it too!! Its happened before!!

Charlie

[Conductor71]

Originally Posted by chasmo

All of you are well within the "symptom progression" window. my last one was 4.5 years in duration. So I do not think that your med protocol has anything to do with it. The placebo effect could be at work.

Of course I could be full of it too!! Its happened before!!

Charlie

Charlie,

As someone who is fairly newly diagnosed, I wonder what the 'symptom progression' window is? Is this a time fairly early on where it seems things are going slowly before they take a turn for the worse?

Thanks,

Laura