Paula hon

I am gving my opinion on what I would like to see happen and in no way asking anyone to do anything. I know what you people have to endure and my heart goes out to you all. But that doesn't mean I am getting soft in my old age.

The fact that you are feeling this way is good in the sense it puts on paper or screen the true undilluted horror of Parkinson's on any human being and on all who are effected.

I will use your words once again to establish my point when necessary.

Everett

What ever help you need that I can furnish just let me know.

Ron

If the premise you lay down that it is a defect in the BBB that allows whatever to enter the brain and cause Parkinsons then it can have a nasal passage as entry. But what of Marinol, I think that is the name. It can be used lin animals to close the membranes after they have been opened by researchers and isn't it being done in humans. I need to look this up.

Your all great and take from me the Cure is coming, Please let it come in time for my friends here.

Thelma

Let's just put it all on a table and look at it. I am fairly sure that we have all said it already. First we have LPS-induced inflammation (quantitative and qualitative according to amount and duration of exposure) causing a corresponding leakage of the Blood Brain Barrier (again quantitative and qualitative according to duration and severity of inflammation), which, in turn, allows entry of any number of neurotoxins into the brain to interfere with processes determined by the toxins size, shape and mode of action.

In this scenrio we have

initiation ( An act that sets in motion some course of events)

potentiation (medicine) the synergistic effect of two drugs given simultaneously)

and

facilitation (neurophysiology) phenomenon that occurs when two or more neural impulses that alone are not enough to trigger a response in a neuron combine to trigger an action potential)
(definitions provided by Easy Office Dictionary)
of not one but any number of neurodegenerative diseases, a majority of which should be preventable by eliminating the innitial cause of the inflammation.

Next:

mchael b.

Thelma,

Thanks for turning my whine into something useful..... paula

Michael,
I have written to Prof Leenders in Holland, who did the work showing all Parkies have a defective BBB. He did not reply. I have also told other researchers in London about the idea. They were not really interested. They have grants to investigate another idea entirely, and they focus only on their own work.
Birte,
You are right in all you say about methylprednisolone, but that was only an example. There must be a whole list of ways to tighten down the BBB.
Thelma has mentioned a compound I have not heard of, Marinol, and rightly points out that you can by-pass the BBB by a nasal route.
However, we need to list known ways of closing the pores, and where the method is not prescription based, to try try them, after checking safety. I have not had time to search for possible treatments yet.
Ron

Ron, Thanks for posting your information. It's very interesting. I hope somewhere along the way a researcher can be found to explore this. I have not had a chance to go to the links you posted but I will be doing that as time permitts.

To everyone else, sorry about not answering the many replies to this thred. They have been outstanding and I find myself reading more than answering. Rick, your right it's scary to see what a few Parkies with keyboards can do in just a few hours. I think I've learned more in the last 24 hours than I have in the last 10 years about PD. Keep up the good work guys!

GregD

Severe loss of function of the blood brain barrier occurs in Meningitis. So if Parkinson's Disease was simply due to a loss of function of the blood brain barrier, why is it that people with Meningitis don't all have Parkinson's Disease ?

Hi Keith,
I preferred the Godfather to Daffy Duck,!!!
Meningitis is the inflammation of the lining around the brain and spinal cord.

Septicaemia is the blood poisoning form of the disease.
It is caused by as bacteria or a virus.

http://cat.inist.fr/?aModele=afficheN&cpsidt=13462338
"Bacterial penetration across the blood-brain barrier (BBB) into the central nervous system is the first step in development of meningitis."
It seems that other factors come into play in Meningitis
which close the pores of the BBB after bacterial infection.
"Anti-TNF-a antibody blocked both the BBB opening and the entrance of circulatory S. pneumoniae type 6 into brain, indicating that TNF-a played an important role in controlling the opening of BBB."
Disruption of the BBB occurs after bacterial infection of the brain, caused meningitis, which is quite different to the long term open BBB we have, collecting toxins and damage over the years. There is a short temporary opening of the BBB in Meningitis, and as you see above, other factors come into play to close the pores. Parkies have a permanent leak, in meningitis it is a short transient disruption.
Your question was quite a good one actually, not the "Quackers" from Daffy Duck, The Godfgather or Keith Bridgeman, but I can't spend time on any more from any of them.
Hope you are selling lots of your brew to Parkies, how are sales going?
Ron

...is a standard menu form in US restaurants where one has the choice from two or three selections for your entree and then from a dozen or so options you choose two or three vegetables.

That is the model for PD for us to consider. My own version has, in Column "A", inflammation with a garnish of hyper sensitivity to LPS (bacterial toxin) or an alterred stress response. From Column "B" you choose amongst mercury, rotenone, manganese, aluminum, stress again, more LPS, a selection of viruses, H pylori, etc.

You don't have to order all of these in order to be a Blue Plate Special but you do have to order the minimum combination - otherwise you are something other than a BPS. So, if you do indeed get a big helping of meningitis-induced inflammation and open your BBB for awhile, but you don't order any toxins with it, then you don't have a BPS.

Conversely, a surge of toxins and an intact BBB still no BPS. Ah, but if you are so unfortunate as to order both that day....

That is the "Many Hits" hypothesis. And now I'm hungry...

I thought this one was interesting, as a number of the neurological diseases are connected, and involve the BBB.
Interesting that this reference suggests MS is actually a disease of the BBB rather than the immune system.

http://en.wikipedia.org/wiki/Blood-b...ier#Meningitis
Multiple sclerosis (MS)
Multiple sclerosis (MS) is considered an auto-immune disorder in which the immune system attacks the myelin protecting the nerves in the central nervous system. Normally, a person's nervous system would be inaccessible for the white blood cells due to the blood-brain barrier. However, it has been shown using Magnetic Resonance Imaging that, when a person is undergoing an MS "attack," the blood-brain barrier has broken down in a section of his/her brain or spinal cord, allowing white blood cells called T lymphocytes to cross over and destroy the myelin. It has been suggested that, rather than being a disease of the immune system, MS is a disease of the blood-brain barrier"
Ron

Ron, I'll stick with the Duck for now.

The "brew" is being subjected to a major clinical trial at Addenbrookes Hospital, the surrounding clinics and hospitals in Cambridgeshire, and in hospitals abroad. We have already seen a lot of people continuously reducing their symptoms after lengthy use. As it does not have any beneficial effect at all on the blood brain barrier, what we have seen in practice does not support the claim that Parkinson's Disease is due solely to a loss of function of the blood brain barrier. It could at most be claimed that it is overcoming to some extent some deficiency of the blood brain barrier.

As the dopaminergic neurons are just one of dozens of cell types in the brain, why is it that a defective blood brain would cause Parkinson's Disease in somebody rather than medical disorders concerning all of the brain cell types that would be affected. You are a good example of this. You have written several times that you can remember 16 digit numbers. Even most twenty year olds can't remember half of that. Short term memory is function of the cholinergic neurons. If you had a defective blood brain barrier why is it that your cholinergic neurons are functioning so effectively. If your blood brain barrier was badly affected you would also have a very limited short term memory due to the effect on the cholinergic neurons, but you plainly don't.