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08-26-2010, 06:08 AM | #1 | |||
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In Remembrance
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From http://www.sciencedaily.com/releases...0815162130.htm
In the study, researchers detected a new association with the HLA (human leukocyte antigen) region, which contains a large number of genes related to immune system function in humans. With the new findings, and link to HLA, researchers will now be encouraged to take a fresh look at the possible role of infections, inflammation and autoimmunity in Parkinson's disease. HLA genes are essential for recognizing foreign invaders from the body's own tissues. Similarly, HLA molecules are supposed to recognize a body's own tissue as itself and prevent immune reactions against them. But the system doesn't always work perfectly. HLA genes are highly variable from individual to individual. Certain variants of the genes are associated with increased risk or protection against infectious disease, while other variants can induce autoimmune disorders in which the immune system attacks the body's own tissues. Multiple sclerosis, a neurological disease caused by autoimmunity, is also associated with HLA-DR. The genetic variant that is associated with Parkinson's disease is in the same region as the one associated with multiple sclerosis.
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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08-26-2010, 12:42 PM | #2 | ||
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Senior Member
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If only researchers would read what Rick and some others have been posting about for years, I can't help but think it would push things forward by light years! Good find, Rick, thanks for sharing.
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08-26-2010, 02:00 PM | #3 | |||
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Junior Member
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Rick,
I am going for my 3 month visit with Neurologist Friday morning. I printed out the article to see if he has any comments. Will report back. Mike |
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08-26-2010, 08:48 PM | #4 | |||
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Senior Member
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There are some creative ways to establish quality control. For instance, their could be patient liaisons or reps and Rick, Ron Hutton, and Girija would be perfect for that (others too). Thanks, Rick! Laura |
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08-27-2010, 08:39 AM | #5 | |||
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In Remembrance
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Heck, if they even cared enough to assign a grad student to liason with us it would be something. The unspoken message is we don't count. Or, to paraphrase George Carlin, "It's a great big club and YOU'RE not a member!"
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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08-27-2010, 12:51 PM | #6 | ||
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Member
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Just wanted to add my two cents worth here. I have tried very hard to initiate discussions with PD researchers on the autoimmune component of PD, sent grant applications to test my hypothesis for atleast 2 years now. All I can say is I havent been successful yet.......... I am still trying....
Girija |
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08-27-2010, 02:34 PM | #7 | ||
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