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09-17-2010, 10:46 PM | #1 | |||
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Funny, I was noting how much I liked Rick's thought in his Stress post:
"There is more in the world than dopamine" When lo and behold, I stumbled upon this little gem reported early this spring. Apparently, scientists have discovered a novel form of stem cell treatment involving embryonic medial ganglionic eminence (MGE) cells. This type of treatment is unique because it completely bypasses the lack of dopamine. Given that with traditional stem cell treatment, the aim is to restore dopamine...only to have the new dopamine cells killed off all over again. With the MGE cells, the GABA neurons are inhibited and it slows down the excitatory process that takes place in PD. Better yet, this may treat more than just PD: The results, the scientists say, demonstrate that the transplanted cells, known as embryonic medial ganglionic eminence (MGE) cells, can very precisely modify the balance of excitation and inhibition in neural circuits to influence behavior. As overactive neural circuits are associated with other neurodegenerative diseases -- a result of nonfunctioning or missing cells or abnormal synaptic transmission -- the finding may have broad implications. The Full Monty I must say things are looking a little brighter these last few days. Laura |
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09-18-2010, 11:28 AM | #2 | ||
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Senior Member
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Laura,
Wow, this is interesting because there is a professor I believe in Ohio, During or Durig is his last name, who also works in New Zealand. He splits his time between the two. He is the guy who is developing a GABA-based therapy for PD. I cannot remember the name of it but it doesn't involve dopamine, rather, like your article, it works on calming things down. We mentioned this to our neuro who is at the forefront of PD stuff and he could have cared less. My take was that he is on the dopamine bandwagon and any treatment that does not target that is not worth looking at. But we are. So interesting to read this, thanks! |
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"Thanks for this!" says: | imark3000 (09-19-2010) |
09-18-2010, 04:56 PM | #3 | ||
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working with Kaplitt and the Neurologix team?
Cal Quote:
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09-18-2010, 06:58 PM | #4 | ||
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An interview with Durig:
http://www.medscape.com/viewarticle/460396 and in the news more: http://www.cornellneurosurgery.org/a...nsDisease.html http://tvnz.co.nz/content/1195234/425826.html and most recently, in the news because it needs funding for a phase III trial (wonder why Fox Foundation is not assisting here?...) http://seekingalpha.com/article/2246...-1-big-concern |
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"Thanks for this!" says: | Conductor71 (09-19-2010), imark3000 (09-19-2010) |
09-18-2010, 08:13 PM | #5 | ||
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If the results from Phase II turn out to be as successful as anticipated, hopefully someone will step up to the plate.
Cal Quote:
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09-19-2010, 06:56 AM | #6 | |||
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Quote:
Anyway, looks like MJFF did fund Phase II. They post a very positive outcome. http://www.michaeljfox.org/newsEvent...cle.cfm?ID=640 Lurking, thanks for the clinical trial history review! Looks like Dr. During and Dr. Kaplitts may be on to something big. This statement from MJFF really hits home for all of us, doesn't it? "While dopamine clearly plays a role in Parkinson's disease, dopamine levels in the brain are inherently difficult to control, resulting in sub-optimal treatment outcomes for patients. We believe that by altering chemical targets further downstream in the brain's network that regulates movement, we have the potential to help improve outcomes and restore motor function for patients with advanced Parkinson's disease," added Matthew J. During, MD, DSc, scientific co-founder of Neurologix, Inc |
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"Thanks for this!" says: | anon72219 (09-19-2010) |
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