This looks interesting!


Caloric Restriction and the Nutrient-Sensing PGC-1 in Mitochondrial Homeostasis: New Perspectives in Neurodegeneration.

Nutrient-Sensing PGC-1 in Mitochondrial Homeostasis?

Yeah, I was wondering about my mitochondrial homeostasis just the other day, when this guy in the subway said "Psst! Hey mister, wanna cop some Nutrient-Sensing PGC-1?"
I said is that the blue pill that makes you smaller or the red pill that makes you taller, or is it the yellow pill that does nothing at all; just ask Alice, when she's ten feet tall.

Actually, I don't understand the science words... something about too much nutrition? Do they propose that we cut down on something?

Laura, if you can read and understand that whole article I take my hat off to you! However, given that the combination of PD and PA has me very immobile and for the first time in many years putting on weight (I have always been big but stayed for many years at a completely static weight) in spite of having little appetite, and no real impetus to eat, this sounds ideal to me, just stop bothering to for most of the time. On the other hand isn't that what many elderly people do anyway?

Either way the combination of trying to read it, and Bobs post had me laughing!

If you are able to summarise what the nutrient sensing bit etc. is about it might help..........

I only said the article looked interesting not that we would understand it.

You are right about this article too; it is a jargon laden gem. My brain shuts down after encountering 3 acronyms. I was really mostly interested in the calorie restriction part as I have read that only one other place. It was good to see more support for it.

The PGC1a is a protein that helps us generate new mitochondria. The higher in fat our diets, the less PGC1a we produce. So the reverse holds true they believe. This is assuming our mitochondria are damaged in the first place

This is my way oversimplified take on it. Lindy, does this sound right?

Laura

What do mitochondrial pathways do? Anyone? Anyone? They provide the pathways for dopamine neurons to travel to the neccessary nerve to stimulate it or stop it. When a woman is nursing, the pathways do not allow the dopamine to enter the breast cell. Instead prolactin is produced and released to produce. When the baby stops suckling, prolactin is not transported, dopamine takes over to dry up the milk ducts.

If overeating damages the pathways, breastfeeding may prove difficult. And if you have a gene mutation that incorrectly blocks the mitochondrial pathways to skip steps in the process of creating themselfs incorrectly so they blokade the dopamine cells, the dopamine may just back up back in the basil ganglia and begin destroying themselves.

There are many different people, I was told, that have something unique to add to the information found here. Laura had something important to add. If you don't understand the information either ask questions or don't post. I find the supposedly humorous poetry to add nothing to this conversation.

Dianna

Hi Laura,
It makes it a bit clearer! Thanks.

You are right about it being interesting. I am not the worlds most consistent meal maker let alone eater, if you get my drift. Missing meals makes me feel better not worse, so when there is an article like this I take a look. Not sleeping has the same effect. But as I have said before over the years, neither of them are things you can do without. I wish there was more on why this is so, and how we can use it to help ourselves. Scientific jargon is hard to deal with at 4 am !

Keep on noticing!

Lindy

Dianna,

Thanks for saying so, but I am not offended. You'll get to know Bob's sense of humor. He was quoting Jefferson Airplane's song lyrics to "Go ask Alice"-- a hippy, trippy tune based on Alice in Wonderland. It made me smile.

Interesting info on mitochondria as transport enabler; I did not know that. I think that in our instance some researchers are saying it is more our mitochondria is impaired so it results in oxidative stress and cell impairment or seloss. PGC alpha 1 expression is also linked to Diabetes and there is actually a PGC 1a agonist in use for diabetic patients that has been suggested for treating PD.


Lindy,

I still do not get how the "nutrient sensing" works.

Nor me, lol.

Far too much jargon and no explanations, but someone in the universe must know! Just not me....

Wow! Quite a post you have there. It is seldom that I am left speechless......

Dianna,
Go to your profile page (User Control Panel), on the left-hand of the page, go to Settings and Options, click on “Edit Ignore List”; there will be a pop-up to add a member to list, type in “Bob Dawson” and save.
All of my posts, past, present and future, will then disappear from your view.

My writing is not going to change.