This is only one person experience of managing MS with B1 injections & Liver Extract plus some supplements. It could have been placebo but the possibility that these injections and supplements might have worked can't be discarded either. There is info on couple compounding pharmacies which provided injectable B1 at that time (2003).

http://www.townsendletter.com/May200...otocol0503.htm

Apparently there is a Thiamine protocol referred to as The Klenner Protocol which has been around since the 1940's! Who knew? Very interesting indeed.

https://aaronjreid.wordpress.com/tag/vitamin-b1/

This paper relates to Alzheimer's but Benfotiamine would seem to be worth the try for PD.

http://brain.oxfordjournals.org/content/133/5/1342

Benfotiamine and fursultiamine are generally considered as lipid-soluble thiamine derivatives with better bioavailability than thiamine (Loew, 1996), although benfotiamine is practically insoluble in oil and several organic solvents (Volvert et al., 2008). Especially, benfotiamine has been shown to be effective on diabetic nerve complications such as diabetic neuropathy and retinopathy (Hammes et al., 2003; Varkonyi and Kempler, 2008). So far, only one clinical study reported that fursultiamine at an oral dose of 100 mg/day had a mild beneficial effect on patients with Alzheimer’s disease in a 12-week open trial (Mimori et al., 1996). To seek experimental evidence for further clinical investigations, here we explored whether benfotiamine and fursultiamine exhibit beneficial effects on cognitive impairment and pathological alterations in a rodent Alzheimer’s disease model: amyloid precursor protein (APP)/presenilin-1 (PS1) transgenic mice (carrying both mutant APP and PS1 transgenes) (Holcomb et al., 1998). Surprisingly, our results suggest that only benfotiamine, but not fursultiamine, is beneficial and the increase in brain thiamine levels does not appear to be sufficient for the beneficial effects.

This case suggests that a high blood thiamine concentration does not necessarily correspond to sufficient thiamine levels in the brain. Thiamine injection helped in this case, too.

http://www.ncbi.nlm.nih.gov/pubmed/20384190

This is very interesting as it once again shows that some folks for some reason are just unable to absorb B1 (and likely other B vitamins) and it causes big problems like that detailed in this paper and may also be at the root of PD, MS, chronic fatigue etc. I wonder if Benfotiamine (a fat based thiamine) and doesn't apparently get processed by the gut but goes to the liver instead, may be nearly as good as intravenous thiamine uptake.

http://en.wikipedia.org/wiki/Sulbutiamine

Has anyone tried this? It apparently is supposed to cross the BBB more easily?

I've wondered for years if the Choroid Plexus may be at the heart of the problem regarding folks that have trouble absorbing B vitamins. Apparently, the Choroid Plexus acts as a filter to protect the brain from mercury etc. so if its damaged by too much mercury maybe the brain can't transport enough B1 to stay healthy.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126155/

" These results were interpreted as showing that the entry of total thiamine into the brain and CSF from blood is regulated by a saturable transport system, and that the locus of this system may be, in part, in the choroid plexus."

http://www.ncbi.nlm.nih.gov/pubmed/1267006

This is interesting - it's about thiamine and Alzheimer's, not Parkinson's - but still very interesting on thiamine/brain.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609887/

There is a very small (n=3) case series which suggests that high doses of thiamine can be beneficial for people with PD:

http://www.ncbi.nlm.nih.gov/pubmed/23986125

The same author Costantini did a similar study with 60 patients in 2012 with the same results. I don't have a link for it but received a copy of it from Dr. Costantini.