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01-30-2015, 01:21 AM | #31 | ||
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This is only one person experience of managing MS with B1 injections & Liver Extract plus some supplements. It could have been placebo but the possibility that these injections and supplements might have worked can't be discarded either. There is info on couple compounding pharmacies which provided injectable B1 at that time (2003).
http://www.townsendletter.com/May200...otocol0503.htm |
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01-30-2015, 09:48 AM | #32 | ||
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Quote:
https://aaronjreid.wordpress.com/tag/vitamin-b1/ Last edited by zanpar321; 01-30-2015 at 10:33 AM. |
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"Thanks for this!" says: | anagirl (01-30-2015) |
01-30-2015, 01:23 PM | #33 | ||
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This paper relates to Alzheimer's but Benfotiamine would seem to be worth the try for PD.
http://brain.oxfordjournals.org/content/133/5/1342 Benfotiamine and fursultiamine are generally considered as lipid-soluble thiamine derivatives with better bioavailability than thiamine (Loew, 1996), although benfotiamine is practically insoluble in oil and several organic solvents (Volvert et al., 2008). Especially, benfotiamine has been shown to be effective on diabetic nerve complications such as diabetic neuropathy and retinopathy (Hammes et al., 2003; Varkonyi and Kempler, 2008). So far, only one clinical study reported that fursultiamine at an oral dose of 100 mg/day had a mild beneficial effect on patients with Alzheimer’s disease in a 12-week open trial (Mimori et al., 1996). To seek experimental evidence for further clinical investigations, here we explored whether benfotiamine and fursultiamine exhibit beneficial effects on cognitive impairment and pathological alterations in a rodent Alzheimer’s disease model: amyloid precursor protein (APP)/presenilin-1 (PS1) transgenic mice (carrying both mutant APP and PS1 transgenes) (Holcomb et al., 1998). Surprisingly, our results suggest that only benfotiamine, but not fursultiamine, is beneficial and the increase in brain thiamine levels does not appear to be sufficient for the beneficial effects. |
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03-07-2015, 10:43 PM | #34 | ||
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This case suggests that a high blood thiamine concentration does not necessarily correspond to sufficient thiamine levels in the brain. Thiamine injection helped in this case, too.
http://www.ncbi.nlm.nih.gov/pubmed/20384190 |
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03-07-2015, 11:12 PM | #35 | ||
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Quote:
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03-07-2015, 11:27 PM | #36 | ||
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http://en.wikipedia.org/wiki/Sulbutiamine
Has anyone tried this? It apparently is supposed to cross the BBB more easily? |
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"Thanks for this!" says: | BreezyRacer (03-09-2015) |
03-07-2015, 11:28 PM | #37 | ||
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Quote:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126155/ " These results were interpreted as showing that the entry of total thiamine into the brain and CSF from blood is regulated by a saturable transport system, and that the locus of this system may be, in part, in the choroid plexus." http://www.ncbi.nlm.nih.gov/pubmed/1267006 |
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03-08-2015, 12:02 AM | #38 | ||
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This is interesting - it's about thiamine and Alzheimer's, not Parkinson's - but still very interesting on thiamine/brain.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609887/ |
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03-08-2015, 01:40 AM | #39 | |||
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Grand Magnate
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There is a very small (n=3) case series which suggests that high doses of thiamine can be beneficial for people with PD:
http://www.ncbi.nlm.nih.gov/pubmed/23986125 |
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03-08-2015, 01:07 PM | #40 | ||
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Quote:
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