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03-08-2015, 09:09 PM | #41 | |||
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Grand Magnate
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Thanks for that zanpar321.
This is a fascinating thread. One thing which I have been pondering is that thiamine is essential for two enzymes, the pyruvate dehydrogenase complex and 2-oxoglutarate dehydrogenase, which play key roles in glucose metabolism, leading to production of, in effect, metabolically useful energy (ATP). Under normal conditions glucose is the only energy source for the brain and it need to continually replenish its ATP (neuro-transmission is energetically expensive). Naively I would have thought that if thiamine levels in the brain were abnormally low then ATP replenishment would be impaired, leading to systemic neurological effects, rather than effects which are confined to people with PD. Does anybody know anything about this? |
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03-09-2015, 04:46 PM | #42 | ||
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I may give it try later and will definitely remember it .. |
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03-09-2015, 05:47 PM | #43 | ||
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http://www.biomedcentral.com/1471-2210/8/10 Benfotiamine that is practically insoluble in water, organic solvents or oil was solubilized in 200 mM hydroxypropyl-β-cyclodextrin and the mice received a single oral administration of 100 mg/kg. Though thiamine levels rapidly increased in blood and liver to reach a maximum after one or two hours, no significant increase was observed in the brain. Conclusion Our results show that, though benfotiamine strongly increases thiamine levels in blood and liver, it has no significant effect in the brain. This would explain why beneficial effects of benfotiamine have only been observed in peripheral tissues, while sulbutiamine, a lipid-soluble thiamine disulfide derivative, that increases thiamine derivatives in the brain as well as in cultured cells, acts as a central nervous system drug. Last edited by zanpar321; 03-09-2015 at 06:23 PM. |
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"Thanks for this!" says: | BreezyRacer (03-09-2015) |
03-09-2015, 06:26 PM | #44 | ||
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Senior Member
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"Thanks for this!" says: | zanpar321 (03-09-2015) |
03-09-2015, 07:09 PM | #45 | |||
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Wisest Elder Ever
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Whether oral or IM or benfotiamine-- it still has to cross the BBB to get into the brain.
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03-11-2015, 02:21 AM | #46 | ||
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Junior Member
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Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects
"Our study demonstrates that high blood levels of thiamine can be achieved rapidly with oral thiamine hydrochloride. Thiamine is absorbed by both an active and nonsaturable passive process." http://www.biomedcentral.com/1472-6904/12/4 |
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03-11-2015, 08:30 AM | #47 | ||
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Last edited by zanpar321; 03-11-2015 at 08:56 AM. |
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03-11-2015, 09:19 AM | #48 | ||
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http://link.springer.com/article/10....0278489#page-2 Last edited by zanpar321; 03-11-2015 at 12:26 PM. |
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