Parkinson's Disease Tulip


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Old 02-15-2008, 06:44 AM #1
imark3000 imark3000 is offline
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Default Any opinions on Melatonine as Antioxidant and Sleep Help?

..Any body taking it?
There is plenty of research for it including the following :

http://en.wikipedia.org/wiki/Melatonin
"In animal models, melatonin has been demonstrated to prevent the damage to DNA by some carcinogens, stopping the mechanism by which they cause cancer.[30] It also has been found to be effective in protecting against brain injury caused by ROS release in experimental hypoxic brain damage.[31] The antioxidant activity of melatonin may reduce damage caused by some types of Parkinson's disease, may play a role in preventing cardiac arrhythmia and may increase longevity; it has been shown to increase the average life span of mice by 20% in some studies.[32][33][34]"
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Old 02-15-2008, 07:28 AM #2
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i don't have pd...but i take melatonin every night. i had insomia for years. would average 2- 3 hours of sleep a night. take me forever to fall asleep.

now i take melatonin and a calcium & magnesium supplement before going to bed. 30 minutes or less..and i'm out. i still wake up from pain, but i can now usually fall back asleep.
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Old 02-15-2008, 07:43 AM #3
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Default Thank you so much

Quote:
Originally Posted by Curious View Post
i don't have pd...but i take melatonin every night. i had insomia for years. would average 2- 3 hours of sleep a night. take me forever to fall asleep.

now i take melatonin and a calcium & magnesium supplement before going to bed. 30 minutes or less..and i'm out. i still wake up from pain, but i can now usually fall back asleep.
.. Can you tell me what dose of Melatonine / Ca/ Magnesium you are taking? and how long have you been taking it?
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Old 02-15-2008, 08:06 AM #4
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the melatonin 3 mg

i just check the bottle of my calcium..it also has vit d.
calcuim 600 mg
vit d 200 iu
magnesium 100 mg

i started this about 6 months ago.

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Old 02-15-2008, 11:29 AM #5
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imark
I also use melatonin but have to take only 300mg or at max 600mg per night

if I take any higher dose it has the opposite effect and makes me very edgy and restless

my doc says that it is likely to do with serotonin levels that different people require such a wide range of doses

It seems best to start on a low dose and then work up if needed

Cheri
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Old 02-15-2008, 03:17 PM #6
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Default nothing is simple - sigh

In the mornings, too much melatonin can block the release of the first dopamine of the day. Sleep deprivation (which lowers melatonin) has been used to improve both PD and depression. As suggested above, start low and gradually increase.
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000.
Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
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