[rd42]

I have a cold and would like to try Dextromethorphan but I'm on Azilect. Has anyone tried this, it's not recommended but then again the drug interactions of Azilect are mostly based on MAOI-Type A and not type B.(I think I read that some where)

Either way I cold use some cold medication, any recommendations?

[reverett123]

They are both processed by the liver (as is requip) which could pose problems. It might be best to rely on the honey-lemon hot toddy approach and experiment later.

Something I discovered last week- About 20% of us are "slow" metabolizers of dex and whereas normal folks clear out half a dose in two hours it might take 24 for us. If we keep taking it like normals then we rapidly build up problematic levels.

The effect in my case was that with just an eighth of a teaspoon I felt a mild but pleasent high the first day and repeated the dose at night. The second day symptoms flared up and by third day it was undeniable.

What tipped me off was that first day high. I should not have experienced that at that low dosage. Dex works in part by shielding a class of receptors called the NMDA receptors. It does this by occupying them momentarily thus blocking glutamine which would have locked on to them for keeps. But because my dosage had not been adjusted to my "slowness" the dex was having a similar effect since there was a lot of competition for the receptors. So, once I get past my mucuna trial,I'm going to try again and literally wet my fingertip and lick it.

Which brings up the question RLSmi (I think) had about the similar action of naloxene and the incredibly tiny dosing used. Is it possible that its effectiveness is a cumulative effect similar to this?

[stevem53]

Originally Posted by rd42

I have a cold and would like to try Dextromethorphan but I'm on Azilect. Has anyone tried this, it's not recommended but then again the drug interactions of Azilect are mostly based on MAOI-Type A and not type B.(I think I read that some where)

Either way I cold use some cold medication, any recommendations?

Some cold medications contain Dextromethorphan in them..I believe that the Sudafed cold gell caps have DM in them..You have to check the ingredients of all cold medications for DM..I take a therapudic dose of DM in hopes of neuro protection, and I check all cold meds for DM as to not interfere with the recommended therapudic neuro protective daily DM dosage

I dont know what to say about DM and Azelict except that if DM use is not recommended while taking Azelict, then you probably shouldnt use it, especially when you take into consideration that you are taking DM to treat cold symptoms, which requires higher, but recommended doses, as opposed to much lower neuro protective recommended doses

[rd42]

My Dr. recommended Benedryl and try talking to the pharmacist who had just told me to call my Dr.

So I'm going to try Benedryl...

[rd42]

At full dosage the Benedryl helped dried up my nose, woke me up then put me to sleep. I would recommend starting with half the dose, one capsule, to see how it goes if you're taking Azilect. I talked with the maker of Azilect and they said to stay away from DM and decongestants.

Robert