Do you suffer a bad "off" immediately after a sinemet tablet wears off?
Does it gradually improve with no further sinemet over the next few hours?
After nearly18 years of PD, my off's in the mornings before I have taken any sinemet, are not too bad. I can get around. However, when a tablet wears off, I am infinitely worse, and cannot walk at all. The "relapse" gradually fades over the next 1 to 2 hours.
A very strange thing is I occassionally switch on without any sinemet. It lasts for up to an hour. However, I suffer the same relapse when the on wears off. I can't help feeling there is a big clue here. The relapse can't be blamed on toxic compounds from the levodops, I haven't had any!!!!
If any of this sounds famililiar, or any ideas, please respond.
Ron