I think doctors are only going by what the manufacturers sales reps tell them...
They don't consider investigating any long term effects from other sources or online...they just rx the latest & newest meds.. per reps anyway...

Not saying all do this, but seems like many of them do.

Off Topic- Jo what does the time & temperature on your sig mean?
The temp outside your door ....or mine? Cuz if its yours, we're much colder here today-it barely broke freezing. I know the time is hours off from my Eastern DST.

I am at 16 in the western great lakes....but the wind is very brisk and it feels a whole lot colder. I can't find the windchill anywhere online. I was in a small pocket that did not get hammered....we only got 12", but it does drift here badly due to the naked cornfields. East and west of us got 6 to 12" more.

Our ground hog was buried and never saw the sun or shadow.....

i think that means spring is never coming.

i have two and a half feet of snow on the ground here and havent seen the ground since 12/26. ithasnt reached 40 since november. very unusual winter for here.

Actually counted all the days for each prediction? Well? Duh? 1-3 days difference [counting leap years].. I just kept asking myself why? Wha? Duh?
Dunno about others? Just would rather do a SUN DANCE! Truly a peculiar weather cycle we are now having?
As for spring coming? Some key birds are migrating north, and passing thru here abouts... No geese or others like them yet tho...I'm expecting them next week, as their migrations are sunlight/sky driven...
I may recant all this late tomorrow? As 'Freezing snow, Sleet, and Ice' are predicted? I really must find a hibernation 'cove'/space in my house for such situations? Could be worst tho? Four feet of snow or worse?
For now? I'll take the 'cat' philosophy: Life is hard, then you nap!
It's a good one for sure.
Hugs and other nice things... - j

BTW? I've been suggested to try taking 'Forteo'? But I'm waffleing about it, for justifiable reasons.... Not sure that for ME? IT would be optimal, not to mention the 'administration' of it! That part gives me willies for cause! - j

j,
Weather update D.C. / Balto area:
Just rain/drizzle and 38-34 degrees all thru the nite
No freezing tonite and sunny tomorrow.
Next weather predicted for Wed-Thurs of next week.
But we always have gotten hammered around here in late Feb.
I'm gettin outta here in a coupla weeks
I'm cruisin' to Nassau/Freeport on the 6th of March for 7 nites.
(They sail right out of Balto now!!)

J

After doing research and having one of my recurrent autonomic storms I have decided to nix any bisphosphonates. I had such a bad autonomic issue on Friday that my ribs are sore from upchucking.

My little guy was in his play pen, waiting for grandpa to get home to take care of him so grandma could go to bed...he was watching grandma wretch, and apparently decided my behavior was some urgent form of communication he needed to master quickly.

In the middle of one of my wretching episodes, here is the baby, 1 year old, mimicking my stance, doing my exact 'yak'. He did 3 good 'yaks', bent over at the waist, and smiled at me, as if to inquire, "Did I get it down grandma? I can do this too!!". Now if he only learned to say 'Up'. I fear I traumatized him....but really, I had no option of when to toss my cookies. I admit, admist the suffering, he made me smile.

I just don't think I am in any condition to take a drug that could cause me any further problems.

J I have read some nasty accounts of some of the IV bisphonate administration too....I just don't know...not for me at this time...maybe at a later time...

But, when one loses enuf bone, that one can fracture ribs or worse with a cough or a wrong step? Well, there's only soo much calcium and calcium combos one can take and still not improve. Particularly if asobtion is low to nil.
Half of it's the devil you know, the other half is the ONE you don't know!
Forteo isn't IV ? It's one of the pin-pricks into the abdomen...weekly
Even tho I get IVIG monthly? I'm still needle-phobic of sorts, at least? I don't pass out now. I can close my eyes for the IV stuff, Doing it myself? NAH!
Can I say? SMART KID! Got it all in one, no?
'a!!!!!!!!!!! - j

PS Weather twidgie on the news today said we are now getting ONE more hour of daylight than a month ago! I'd do a silly dance? But, likely fall over!
Hugs and fun for some reason to all!

Yay, one more hour of daylight. Let us dance on our brittle bones!

Yes, I DO understand the quandry.

Right now, my bone density is OK....I don't know what choice I will ultimately make. I am having such autonomic issues, that I wonder if disturbing my bone metabolism is a good idea....when I say bone metabolism, I mean, bone is active on a minute by minute basis in electrolyte balance....it is all so scary.

HEY....may the best team win today, LOL! I can't get too worked up over the game lest I blow a gasket again and end up in the ER....but, well....I am inclined to cheer for the cheese.

I am hoping MrsD cruises thru this post and helps me a bit here....but I am entertaining all opinions and explanations.

When bisphosphonates are taken, and they 'kill' osteoclasts, do the osteoblasts replace bone with the normal amount of calcium or does actual bone composition change? I mean, is the resultant tissue, still metabolically active bone, or something else?

I have read that after IV bisphosphonates are given, there can be a huge release of T cells in some people.

I am just curious, outside of the bone issues, wouldn't all this affect your body's calcium metabolism for the duration of the drugs action? Would this not also affect other functions where calcium is key? (Yep, most of the body, since Ca is the mainstay of connective tissue).

Am I crazy to be so paranoid of this idea given I am living in a body with substantial autonomic dysfunction including 'autonomic storms' and no one seems to really know what is causing all this?