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Old 06-24-2012, 11:56 AM #2
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Neurontin does not affect gaba directly. It is thought to affect calcium ions in nerve transmission.

Quote:
Gabapentin was initially synthesized to mimic the chemical structure of the neurotransmitter gamma-aminobutyric acid (GABA), but is not believed to act on the same brain receptors. The mechanism of action that leads to its rapid analgesic effect is simply unknown.

Some of its activity may involve interaction with voltage-gated calcium channels. Gabapentin binds to the α2δ subunit (1 and 2) and has been found to reduce calcium currents after chronic but not acute application via an effect on trafficking[40] of voltage-dependent calcium channels in the central nervous system.[41] Another possible mechanism of action, reported by Ben Barres and colleagues in Cell in 2009, is that gabapentin halts the formation of new synapses.[42]
from http://en.wikipedia.org/wiki/Gabapentin

I am not aware of any gabapentin effects on inflammation.

I use AlkaSeltzer original formula for pain and aspirin.... it is less likely to cause GI bleeding in solution, because it is absorbed so quickly. Generic form at WalMart is very very inexpensive.

Recent meta analyses of previous papers, have revealed that gabapentin does not work for everyone. Average success is about 30% of patients.
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