Reply
 
Thread Tools Display Modes
Old 09-13-2012, 07:07 AM #1
mrsD's Avatar
mrsD mrsD is offline
Wisest Elder Ever
 
Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
mrsD mrsD is offline
Wisest Elder Ever
mrsD's Avatar
 
Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
Lightbulb

From what I can see in some of the papers, PEA is not water soluble. Hence it would be difficult to get oral products made for oral use. Some of the papers on animals used injection.

http://www.hmdb.ca/metabolites/HMDB02100

More about solubility:
http://www.funakoshi.co.jp/data/datasheet/CAY/90350.pdf

This site explains the sachets are "ultra Micronized" for sublingual absorption. This means the particle size has been made very very small. I begs the question about the actual usefulness of the oral tablets, if the sachets need to be used first. I would wonder if the lack of side effects means not much is orally absorbed in the first place!
I cannot find bioequivalent data on absorption of PEA... drugs for example always have this data available.
http://www.ergomaxsupplements.com/no...00mg-tabletten

Here is the patent information:
http://www.freepatentsonline.com/y2011/0171313.html
This product is specially produced with micronized product with a patent present. Hence you cannot get the PEA yourself and try it on your own, because it might not be absorbed at all.
__________________
All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei

************************************

.
Weezie looking at petunias 8.25.2017


****************************
These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.
mrsD is offline   Reply With QuoteReply With Quote
Old 11-07-2012, 10:16 AM #2
bent98 bent98 is offline
Member
 
Join Date: Oct 2011
Posts: 170
10 yr Member
bent98 bent98 is offline
Member
 
Join Date: Oct 2011
Posts: 170
10 yr Member
Default

Quote:
Originally Posted by Michael777 View Post
Quote:
Originally Posted by mrsD View Post
From what I can see in some of the papers, PEA is not water soluble. Hence it would be difficult to get oral products made for oral use. Some of the papers on animals used injection.
I have read quite a bit about palmitoylethanolamide, being a biologist, and various animal studies published used oral palmitoylethanolamide with positive results. The newer version of palmitoylethanolamide in Normast and in a new supplement PeaPure can resorb quite well under the tongue, and one cam measure not PEA but 2AG rising in the blood. PEA analytics in the blood is highly complicated and not usefull, as the compound shuttles into cells very quickly. PEA both in Normast as well as in PeaPure dissolves in the mouth quickly and vanishes without the first pass effect. Therefore sometimes migraine patients even use it to couteract an attack...
I would give it a try but its alot of money. My gut tells me Normast it self is a scam. How can we verify the contents of it since it is a supplment?

I would be willing to try it if they sent me some for free.

Last edited by mrsD; 11-07-2012 at 10:55 AM. Reason: fixing quote tags for clarity
bent98 is offline   Reply With QuoteReply With Quote
Reply


Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
Significant pain reduction in chronic pain patients after.. (study) Sandel Reflex Sympathetic Dystrophy (RSD and CRPS) 14 06-07-2010 01:20 PM
chronic neuropathic pain only if one has a chronic desease? filipe Peripheral Neuropathy 1 12-12-2009 06:46 PM
Gene Variation affects pain sensitivity and risk of chronic pain - NIH press release fmichael Reflex Sympathetic Dystrophy (RSD and CRPS) 2 10-26-2006 06:35 PM
Gene Variation affects pain sensitivity and risk of chronic pain - NIH press release fmichael Chronic Pain 0 10-26-2006 03:35 PM


All times are GMT -5. The time now is 09:23 PM.


Powered by vBulletin • Copyright ©2000 - 2025, Jelsoft Enterprises Ltd.

vBulletin Optimisation provided by vB Optimise (Lite) - vBulletin Mods & Addons Copyright © 2025 DragonByte Technologies Ltd.
 

NeuroTalk Forums

Helping support those with neurological and related conditions.

 

The material on this site is for informational purposes only,
and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider.


Always consult your doctor before trying anything you read here.