I started at 500mg a day for Bromelain enteric coated. The first few days, I had some stomach/intestinal upset. So I didn't increase quickly. That settled down, and might have been because of my drug induced lupus from the lisinopril I was given for blood pressure.

Also the lisinopril increased bradykinin, and I had that to deal with...angioedema..where your internal organs swell up.

Now I finished the first bottle of LEF bromelain and I am more stable. So I am going to increase to 2 a day (1000mg) and see what happens. My use is different probably from yours. But I do see a general decrease in joint pain as well. (but that may be the reduction of the lupus reaction ...can't tell yet).

I used SAMe for over 10 yrs. I had a very bad right knee and after MRI and an Ortho evaluation, I decided to do the SAMe.
It is really good. Slow on joints, but good.
SAMe was developed by NatureMade to be stable and useful orally. So I stay with them. They have a $7.00 coupon you earn with about 3 packs or so. The price has come down in a major way, and Costco is where I get mine. Start at 200mg a day for about a month to see if you get hyper from it. That is the major side effect IMO. Take it in the morning on an empty stomach, and see what happens. You can get the generic at Walgreen's or RiteAid in the 200mg to start. Within a month you should see if you tolerate that once a day.

The NatureMade coupon program is online. Just search them for details. SAMe is really good for arthritis. And it really saved me surgery for a knee replacement. But that will take some time, so be patient. Some people just can't deal with SAMe...it makes them irritable, or hyper. That cannot be predicted so you just have to try it. At least now it is not so expensive like when I started it so many years ago!

Mrs D..Thankyou so much for all this wonderful information...I live in Newzealand so was going to buy from I herb not sure if naturemade will post to nz. Thankyou again

Then select a brand that comes in a BOX blisterpacked in foil.

When SAMe first came out, generics did not package it like NatureMade does properly. SAMe is light and moisture sensitive and degrades very quickly in bottles.

I worked up to 600mg a day in the morning before eating.
Wait about an hour so the SAMe passes out of the stomach.
I had it with my tea.

Start at 200mg a day for at least 2 weeks to a month. You can
work up slowly over 3 months or so to 600mg a day. 400mg is
sometimes enough for some people.

This is a search from iherb...
http://www.iherb.com/search?kw=SAMe&x=19&y=6#none
You can see the boxes... choose one of those.

I see the pet doses are now available on there. My old dear late cat Sheba took SAMe for 3 months at 50mg doses! It cost $24 at our vet for 30 back then. Vets use it mostly for liver problems in animals but I think arthritis too now.

Im a newbie at this but am learning. Turmeric is more readily absorbed with black pepper and oil. I have a good source of culinery turmeric and put it in a tablespoon with black pepper and California olive oil and it works. One site I saw said pepper increases turmeric bioavailability by 2000% but I don't know if that is true. My turmeric may not be as strong as refined cucurmin but it has worked and helped the inflammation of my COPD.

I am also trying to get quercetin and the bioavailability of that is apparently increased by bromelin. Im not fond of tough apple skin (where the good stuff is) but a tasty treat is apple put through a food chopper, add pineapple chunks and sprinkle with cinnamon or cloves.

There has been some prelinimary research showing the antioxidents attenuate inflammation in COPD and help stop steroid resistance. I got rid of the stupid Spiriva (yay! ) and am able to walk 30 minutes non stop without my O2 levels dropping too low for the first time in memory, maybe ever.

I know this wasn't your question but if it will work for me it must be good.

judi

Hi Judi
Thank you for replying I am so pleased that these things are working for you. Can i ask a bit more about your tumeric do you just mix this up and take it in a teaspoon.
Many thanks Heather

Hi Judi
I hope you get this message I now have copd and would be very interested in what you take

Hi Mrs D
Firstly so sorry to hear that you are having problems and I am amazed how medactions from doctors can cause such horrible things.
I have neuropathy in my legs and as well as crp.
I have started taking the bromelaine at 500 mg and want to increase to 1000 mg can i take this at the same time every morning or should it be a different times.
I bought the sam e and took it for one morning but made feel terrible the same thing happened with 5HTP so I guess I just cant take anything like that which is a shame.
Do you know about Quercetin and and is this okay to add in with Bromelaine
Also one more question do you know if innerzyme is any good I have heard that it is good for inflamation
Many thanks for all your help
Warm regards Heather

I looked up Innerzyme for inflammation:
http://www.innerzyme.com/Systemic_Enzyme.html

My bromelain product is far stronger. LEF's is 500mg with 2400 GDU/gram by comparison.

Also Innerzyme's other things... I can't really say...but you do have to take up to 8 tablets a day!
That supplement detail on the site is for 4 tablets

I am getting a good response from just the Bromelain.
Innerzyme is much more expensive, for a 40 days supply.
I get 60 LEF's bromelain for about $15 and take one or two a day.

You can take other antioxidants together. You can take the bromelain anytime. I try to do it on an empty stomach however for best absorption. Stomach acid is lower on empty stomach too.

Hi Mrs D
Thank you I have just found your other replies so thank you so much.
I am taking the LEF bran as well and will follow what you are doing.
Can you tell me if I want to take Bromelane for digestion should i take the tablet that is not entric coated or does the other work for that as well.
Many thanks

for digestion, I think the uncoated, chewables would be an
option. They are very inexpensive compared to the LEF one.