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Old 06-20-2013, 03:49 PM #1
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Default Edema in feet

Yesterday my feet swelled up pretty bad. I went to the doc this morning and he thinks it's from the mirapex I'm taking, because it's the last drug I added and edema is one of the rare side effects. Checked my vitals and they were all perfect (because something has to be working right). My feet are always cold, so I was worried about the swelling and my circulation.

Doc admitted so much of medicine is a guess (which we know, but it's nice he acknowledges it). I'm going off the Mirapex for two weeks to see if it gets better. If not, then I let him know. He's only a GP, but my neuro is retiring in a few days so I felt it was useless to call him. I'm trying to find a new one.

Anything that I should know about edema and neuropathy? I don't even remember getting such huge feet when I was pregnant. So this is really odd for me. Pain doc is worried I might have MS (good MRI but still too many symptoms). I just keep adding things to my list of problems.
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Old 06-20-2013, 05:00 PM #2
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Are both feet equally swollen?

Try the Magnesium lotion on them... that takes down my left foot with a couple of hours!

Keep elevated too when at home.
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Old 06-20-2013, 05:55 PM #3
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Yep, both feet equally. I think my legs as a whole have been swollen, but I can only tell in my feet (my knees have been hurting the past couple days and my pants are a bit tighter than they normally are). I did an epsom salt soak last night and have been taking my magnesium, so I'm not sure that'll help it. It was the first thing my DH thought of though.
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Old 06-20-2013, 06:15 PM #4
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When both legs and feet are equally swollen that suggests a systemic problem, either with the kidneys or heart.

But then it is difficult to say what is really going on with you.
Hypothyroid is also a possibility.

This doesn't sound like PN ... there is something else going on, I suspect.
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Old 06-20-2013, 06:32 PM #5
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All my vitals at the doc were good. BP 114/82 (usually 110/70).
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Old 06-20-2013, 06:52 PM #6
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I have PN with edema in both feet & lower legs. Eliminating carbs and walking have the most effect on reducing it. Just something to consider if it turns out not to be the mirapex.

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Old 06-21-2013, 02:27 AM #7
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Are you still on that carbamazepine? This drug can cause edema.
This can signal possible hyponatremia developing.

You need to discuss this with your doctor. Over time toxicity to it appears, sometimes suddenly:

http://www.rxmed.com/b.main/b2.pharm.../TEGRETOL.html
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Old 06-21-2013, 03:17 AM #8
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Of course it is important to rule out other conditions or problems that can be causing this. For myself though I have RSD and PN I have severe edema in my feet. Especially in humidity I go up 2 shoe sizes. I also notice that it feels like have lack of circulation in mylower limbs. Other then humidity I don't notice a connection though sometimes being on them too much causes this as well. Overall I try to watch my salt intake. I do try to keep moving so I wonder are you able to do some activity or even go into the pool? If you keep your feet up does it help? Since your doc thought it may be from the meds did he feel you should switch meds or wait?
I hope you get some answers and of course relief.
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Old 06-21-2013, 11:26 AM #9
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I'm on oxcarbazepine, not carbamezepine. It appears that it's a really rare side effect from that.
http://www.ehealthme.com/ds/oxcarbazepine/edema

I did go out for a walk last night, we went to the farmer's market/weekly town street thing so I could get fruit and see a friend's daughter do a dance performance. Then came home and put my feet up. I was finally able to see my bones again I'm going to take my daughter to the city pool tomorrow. My husband also massaged my legs last night. It hurt terribly, but I could feel things moving around a bit.

I'm already on thyroid meds. Last couple times my blood was checked it was a good level. Supposedly the oxcarbazepine depletes my sodium levels. I started twitching not long after taking it. I have been taking magnesium for that, and putting salt on things when I remember, but I really don't use much salt at all (and we don't eat much prepackaged food). But I don't think I've ever had that level checked.

We'll see how things go today, as I have to sit my butt on my chair at work. I do try to get up as much as possible.
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Old 06-21-2013, 11:50 AM #10
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Both of those drugs have the same potential toxicity profile.

The only small benefit from Oxcarbazepine
is that it has slightly different metabolic pathways in the liver, so some of the drug interaction risks are lower for it.

Don't ever underestimate this drug... rare is not really rare.
Some terminology comes from the drug companies themselves and they don't reveal the truth often.

This is a link with reports to the FDA as a basis for comparison:

http://www.drugcite.com/?q=Trileptal
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