I would be very skeptical of the idea that exercise can make your PN worse. The neurologists at Mayo Clinic in Rochester told my mother and I that increased activity will not make our conditions worse. And this goes against everything I have read. Exercise does a myriad of good things for the body, including influencing which genes get expressed. With exercise (and plant foods) the good genes are enhanced and the bad genes suppressed. Here is an article I found on the subject, but search for yourself and you will find many more:
http://healthland.time.com/2012/03/0...hange-your-dna

It is quite possible that you will have more pain temporarily after exercise, but in the long term I believe it is nothing but good.
Ron

Not for a CMTer. I'm sure it is different for others.

I think that if one has damaged cells, with damaged mitochondria, which is one current theory about PN now and other diseases, that exercise would be limited by that damage.

You might be able to do some, but not what you would like or what others might tell you to. The mitochondria process glucose and fatty acids, for energy, for the muscles etc. And if they don't work properly, you are limited by that loss.

I think CMT would fall into this category of poor metabolism.

In other words, don't push...pay attention to what is weak and set limits. One sign would be a lack of tolerance ...if you build slowly and hit a wall and can't get past it...that would be a poor sign for further exercise limits.

Low to moderate intensity as advised by a physical therapist. Not exercising to a point of exhaustion, cutting back and if the pain lasts for more than 48 hours after exercising a CMTer has done too much.