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Old 06-24-2014, 08:56 AM #16
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mrsD mrsD is offline
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Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
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Yes, there can be an irritability factor with SAMe... but I find for myself, that it wanes, as time passes. The first 2 weeks to a month can be very energizing.

If you back off to 400mg a day or alternate 400 with 600 every other day you may find it less irritating. I think one should remain flexible because everyone has different neurotransmitter status, and these doses are very broad and there is not way to identify yet how much people would need, other than trial and error.
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