One really good podcast is by a group of functional medicine doctors at The Center for Bio-individualized Medicine. You can find it on iTunes or can steam it from their website. They have lots of information on reading and interpreting your 23andme genetic profile; they have talked extensively about methylation. You could also goggle methylation on iTunes and see if other podcasts. Good luck.

So you will have to add methylfolate to your supplements
And raise your B12 to 5 mg a day at least.

Exactly, methylfolate was what I am thinking of.

Interestingly enough, it also shows a mutation which makes me vulnerable to celiac disease/ gluten sensitivity, and also some vitamine D absorption issues. I'll get them both tested.

Good thing you got the testing... now you can work around the mutations perhaps and regain some lost functions.

If you have Celiac and don't know it, you could be malabsorbing many other nutrients. So going gluten free may be a good idea, too.

Been doing that already, but not very religiously. Now I have a reason to be systematic about it.

That spells no more eating out so much Which is not a good news, because cooking with two bad hands is a pain in the .. hands. Can anyone recommend a good cooking book for going gluten-free?

There are a lot of sites on line for gluten free, and many restaurants are now offering a gluten free menu to accommodate their patrons. Both Sam's and Costco offer a variety of GF these days. It's a lot easier to be GF today than just a short time ago.

Yes, I did gluten free for 3 yrs almost a decade ago...

But there is really no GF bread like real bread... it is very hard to give that up. A good baguette..how one can long for that!

Buckwheat pasta and Tinkyada are good... but it is difficult to find buckwheat around here. Only one store 1/2 hr away. Tinkyada is a bit easier to find though. When we get the buckwheat we buy 3 or more packages... as Amazon is too expensive for it.

I had my genome run by 23andme before the FDA stopped them from doing all the tests. Best $99 I ever spent. They are negotiating with the FDA and hoping they can once again offer this feature. I truly learned a boatload about my body including drug intolerances, and other issues I have. (3x more likely to have Celiac, alpha actinin deficiency, myoadenylate deaminase deficiency...)

The problem is most doctors are not set up to work with genome data. :/ Especially if it is a LOT of data which I got from 23andme. Now they just do ancestry, but, you can still get medical data by running your genome thru 23andme, downloading your data to your computer, and then running it thru Promethease for free. You do need a bit of medical knowledge to interpret it all tho.