there is a screening test before starting Imuran. The MG posters talk about it. You are supposed to get this test before starting the drug...

http://labtestsonline.org/understand...tpmt/tab/test/

My consultant did mention blood tests needing to be done but I assumed he just meant routine autoantibodies. My GPs will say I have to have all screening tests done and have a clear bill of health re this chest infection - said it would probably be a month or so before I can start. I just really hope it works and I can get my life back on track. Thanks for sending me this link - it helps explain what they are looking for. Mat

Hi Mat, I might mention this to my rheumy when I see him at end of the month. I have full body autoimmune probems, ankylosing spondylitis, psoriasis, uveitis, stomach problems, tinnitus, now SFN. This has to be a manifestation of systemic autoimmunity. Good luck with Imuran. Jo

I fully agree Joanna - and it was the first time he has spoken of multi-system autoimnunity in connection with my own journey. Very interesting. Like yourself I would have welcomed the opportunity to try IVIG infusions over another immune suppressant but we are both using a beleaguered NHS and unless CIDP or MMN or one of the rare immune mediated neuropathies (demyelinating) clearly shows up through blood tests, CSF or nerve conduction tests this would not be offered. I do know someone who does get it for her SFN but she has been very lucky with her postcode area and her enlightened specialist. Imuran is defintely my best option for now I feel. I noticed the SFN went away briefly when I was back on Methotrexate injections last year. The doctors assumed it was secondary Raynauds as I was taking Nifedipine at the time. But I'm quite sure it was the MTX.

It is interesting that the burning pain in hands and feet have eased recently - ever since the flu came on. But I do have lots of other nerve pain and my legs feel cold and wet - feet like ice blocks. My GP took tissue samples from each calf to send off to Edinburgh on Wednesday. It will be interesting to get the results but I told my rheumy I'm not expecting anything to flag up now.

Good luck and I'll keep my eye out for your future posts. Feel free to PM if it helps. Mat