[mrsD]

Well, we do age, and with age comes changes in metabolism.

I have a few questions UTGrad...

1) when you have the tingling etc, is it all the time, or only when you run, or say are hungry? Does it go away with food consumed?

2) do you smoke and/or drink alcohol?

3) what is your diet like? Running puts a huge load on magnesium and B6. Most Americans do not consume enough magnesium daily to match the RDA for it. Magnesium is involved in the actions for energy production in the mitochondria.

4) I do think there is a possibility for you that your exercise regimen has reached some upper limit of tolerability. People all vary in how they can sustain stressful exercise, and as we age the mitochondria may be aging too. We have had younger PNers here who were pushing their limits. One fellow had extreme pain in his palms and wrists, and we finally found it was due to his pushups. He stopped them for a long period and his pain stopped. Pain is a warning sign, and running in the presence of nerve symptoms is not a good idea. Could you walk instead, and cut down from 4 miles walking to one?

5) a good thorough evaluation with Xrays of your feet might be in order at a podiatrist. Too tight of lacing of your shoes can compress the nerves in your instep and create compression symptoms, which may linger throughout the day do to the repeated daily running.

6) do you take supplements? Energy drinks, nutrition bars? Many cereals today are fortified with B vitamins. If you take supplements and took them the day of your blood work, the B12 and B6 would show a false elevation. If so 500pg/ml for B12 as a false elevation is not a good result. The B6 may be also due to consumption of B6 that you didn't pay attention to. It is also not a common test, and the labs may have used old calibration material and the test may be inaccurate as a result. The ranges used by labs were made from volunteers who were NOT using vitamins or fortified foods at the time of the testing.

Originally Posted by mrsD

Well, we do age, and with age comes changes in metabolism.



I have a few questions UTGrad...



1) when you have the tingling etc, is it all the time, or only when you run, or say are hungry? Does it go away with food consumed?



2) do you smoke and/or drink alcohol?



3) what is your diet like? Running puts a huge load on magnesium and B6. Most Americans do not consume enough magnesium daily to match the RDA for it. Magnesium is involved in the actions for energy production in the mitochondria.



4) I do think there is a possibility for you that your exercise regimen has reached some upper limit of tolerability. People all vary in how they can sustain stressful exercise, and as we age the mitochondria may be aging too. We have had younger PNers here who were pushing their limits. One fellow had extreme pain in his palms and wrists, and we finally found it was due to his pushups. He stopped them for a long period and his pain stopped. Pain is a warning sign, and running in the presence of nerve symptoms is not a good idea. Could you walk instead, and cut down from 4 miles walking to one?



5) a good thorough evaluation with Xrays of your feet might be in order at a podiatrist. Too tight of lacing of your shoes can compress the nerves in your instep and create compression symptoms, which may linger throughout the day do to the repeated daily running.



6) do you take supplements? Energy drinks, nutrition bars? Many cereals today are fortified with B vitamins. If you take supplements and took them the day of your blood work, the B12 and B6 would show a false elevation. If so 500pg/ml for B12 as a false elevation is not a good result. The B6 may be also due to consumption of B6 that you didn't pay attention to. It is also not a common test, and the labs may have used old calibration material and the test may be inaccurate as a result. The ranges used by labs were made from volunteers who were NOT using vitamins or fortified foods at the time of the testing.

1) Tingling is intermittent but not tied to anything directly. If anything it is relieved by getting up and moving around. Sitting still in the evenings it's worse.

2) don't drink alcohol at all. Haven't had a beer in 2 years. I do dip snuff.

3) Diet is healthy and balanced. I'm 5'10" and 157 lbs. healthy weight

4) I guess but don't want to lol

5) Not really a question

6) I was taking a Centrum a day and fish oil.

Caffeine and stress does make it worse.

[mrsD]

I'd start by changing your Centrum to Centrum Silver.

Centrum has iron in it... the Silver form does not. Iron for males is not recommended in supplement form unless your doctor tells you to use it.

Did you have CBC run? was your iron high? Was your ferritin high? If so, you could have a genetic disorder that may be overlooked by doctors, called hemochromatosis...this leads to PN symptoms. It is serious. It is often only found when extreme damage starts in the liver and other organs. Some people develop bronzing of the skin(looks like a tan), but that may come later in the disorder.

Change that Centrum or take a men's formula vitamin instead.
It may be worth your while to use a good magnesium supplement like SlowMag... or a chelate of your choice. Just avoid OXIDE form. Choose foods high in magnesium to support your exercise routines. I'd cut back for a while and see if you observe any changes in symptoms.
Information on diet and SlowMag here:
http://www.slowmag.com/
one tablet twice a day is enough for most people.

Some people develop tingling and other PN type symptoms when their blood sugars get LOW.... this is a starvation thing...as the nerves react when they don't get enough nutrients and glucose. Nicotine is a vasoconstrictor and as such also impacts circulation which shows up first in feet and hands.
Get shoes with a wide toe box, and don't lace them too tightly to reduce compression there.

Sometimes just making some lifestyle changes, will help. Start slow and sometimes that is all you need.

[jurgen975]

How high is the b6 in that multivatamine your taking?

http://www.ncbi.nlm.nih.gov/pubmed/16320661

Originally Posted by jurgen975

How high is the b6 in that multivatamine your taking?



http://www.ncbi.nlm.nih.gov/pubmed/16320661

Thanks....not that much. I started the vitamin with 300% RDA B6 after the tingling started. Before the tingling I was only taking a standard Centrum.