Sorry, I missed your response, and haven't been around much the past several days.

You are basically correct. This is what I did:

1. Got the 23andme test (around $100) - that provides raw data on more or less everything, but very little in the way of analysis.

2. I used promethease to analyze my 23andme results - I believe that was $10

3. Promethease identified some MTHFR issues, so I got the Genetic Genie Methylation Profile (free). That showed the methylation issues pretty clearly in a color coded form (green=normal, yellow=heterozygous, red=homozygous)

They you can do some Google searches to find out more info about what it all means and how to treat it. I had some concerns about privacy, but those sites seam to be on the up-and-up. I haven't been bombarded with e-mails, no false credit card charges, etc....

Or, as you indicated - you can just try supplementing with B6, B12, and methylfolate and see what happens. Those are the main supplements to deal with methylation issues. One thing that I did tweak as a result of having the A1298C mutation is the type(s) of vitamin B-12. While most people here recommend the methyl form - some sites recommend using all 3 of the active forms if you have the A1298C mutation. I take a multi-vatamin that has some of the hyroxo form, and alternate between the methyl form and the adenosyl form on a daily basis.

I'm not necessarily recommending any of this to anyone else - but it has seemed to help me somewhat in at least stabilizing my condition. On the other hand, the nature of this illness is so unpredictable there's no way to know for sure what causes improvements or progression.

Thank you so much, Ragtop. I appreciate this information and the step by step. I'm going to consider this. Honestly, I'm reluctant to know so much information. I'm not sure how I'll deal with it. I'll have to think about it.

I'm glad it worked for you. I may try supplementing first and then see what happens. Regardless, I'll keep an eye out for all this now that I know thanks to you and MrsD.

Which B12 do you take? Which brand I mean?

I hope things are going well with you - I can't recall what your situation is like exactly, but wishing you the best.