I have SFN and POTS , and my main problem is disabling fatigue.
I got 2 Rituximab infusions, the last one was 5 weeks ago. I was told it might take 1.5-2 months till it works. I don’t feel any improvement yet, I am very tired probably more tired than before the infusions.

Is the effect of the rituximab gradual ? Should I expect any effect after 5 weeks, or is it too soon ?

My skin biopsy result showed severe reduction of nerve fibers. My main symptom is reduced sensation, I also got tingling, burning, numbness etc. If my SFN is caused by autoimmune disorder can the rituximab restore the sensation ? or the best case scenario is it would stop the gradual deterioration ? how long can it take to feel the effect ?

Can the worsening of the fatigue be caused of the rituximab ? should I ask for any tests ?