Question about different versions of Niacin

mrsD · 04-19-2008, 03:47 PM

I know WalMart is good. They have a good selection, even better than pharmacies. (their SAMe however is less good). I get SAMe at Costco, or when the pharmacies have the buy one get one free sales.

I get my methylcobalamin, inositol powder for hubby, r-lipoic and benfotiamine at iherb. Inositol at iherb is 11.00 for 8oz of Jarrow pharmaceutical grade, and $67.00 or more locally in a store for comparison. When I get carnitine, I get it at iherb too.

I decided to look up inositol hexanicotinate on PubMed. There is a paucity of papers after the late 70's. That is when statins started coming on the scene I guess.

But I did find THIS one that suggests you should take your niacin or non-flush AT NIGHT....

Quote:

J Clin Invest. 1973 Mar;52(3):732-40.Click here to read Click here to read Links
Diurnal patterns of triglycerides, free fatty acids, blood sugar, and insulin during carbohydrate-induction in man and their modification by nocturnal suppression of lipolysis.
Schlierf G, Dorow E.

Previous studies have shown that carbohydrate induction of hypertriglyceridemia in normal subjects occurs at night and appears to be related to a rise of free fatty acids after diurnal feeding of high-carbohydrate formula diet. The present investigation was undertaken to observe the effect on 24-h triglyceride, free fatty acid, blood sugar, and plasma insulin profiles of inhibition of nocturnal lipolysis by glucose or nicotinic acid in normal subjects and in patients with type IV hyperlipoproteinemia.In 10 normal subjects and 10 patients with primary type IV hyperlipoproteinemia, plasma triglyceride, free fatty acid, blood sugar, and insulin levels were followed in short intervals for 24 h while a 2,400 cal, 80% carbohydrate, fat-free formula diet was given in six equal portions during the day (control experiments). This procedure was repeated in the same subjects, 10 of whom (5 normal subjects and 5 patients) received additional feedings of glucose between 2000 and 0600 h while the other 10 persons (5 normal subjects and 5 patients) were given nicotinic acid by intravenous infusion during the same time interval. Both procedures resulted in maintained lowering of free fatty acid levels over 24 h. Mitigation of carbohydrate-induced hypertriglyceridemia appeared to result from the additional glucose in normals and in patients. Nicotinic acid abolished the nocturnal rise of plasma triglyceride levels which in the control studies of normal subjects had resulted in approximate doubling of triglyceride levels in 24 h.The effectiveness of nicotinic acid in inhibiting nocturnal lipolysis and preventing carbohydrate-induction of hypertriglyceridemia might have consequences for management of endogenous hypertriglyceridemia.

PMID: 4685092 [PubMed - indexed for MEDLINE]

There was another paper like this too.

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