Neuropathy and Vitamin D

amit · 11-09-2008, 11:35 AM

Do any of you know of any connection between Vitamin D deficiency and neuropathy?

mrsD · 11-09-2008, 01:40 PM

read this:

http://www.liebertonline.com/doi/pdf...93?cookieSet=1

Mark here has already posted benefits since he started Vit D
supplements.

amit · 11-09-2008, 05:05 PM

but I couldn't open the link.

I started to take vitamin D 2 days ago.

mrsD · 11-09-2008, 05:19 PM

It is a PDF...if you don't have Adobe reader?

try it again, maybe a glitch?

The article is about Vit D healing damaged axons.

darlindeb25 · 11-09-2008, 07:19 PM

I can't open the link either, and I do have Adobe Reader, even the new updated Reader 9. It says our computers do not accept cookies, but that isn't true either...I think it may be a bad link.

I would like to read about neuropathy and Vitamin D though. Thanks

mrsD · 11-10-2008, 08:07 AM

I have Mozilla as a browser and it opens it.
I got this link from another forum, and we cannot link to there.

I don't know how to copy PDFs either.
here is a quote from it that was posted at the other place:

Quote:

To date, the use of autograft tissue remains the “gold standard” technique for repairing transected peripheral nerves. However, the recovery is suboptimal, and neuroactive molecules are required. In the current study, we focused our attention on vitamin D, an FDA-approved molecule whose neuroprotective and neurotrophic actions are increasingly recognized. We assessed the therapeutic potential of ergocalciferol—the plant-derived form of vitamin D, named vitamin D2—in a rat model of peripheral nerve injury and repair. The left peroneal nerve was cut out on a length of 10 mm and immediately autografted in an inverted position. After surgery, animals were treated with ergocalciferol (100 IU/kg/day) and compared to untreated animals. Functional recovery of hindlimb was measured weekly, during 10 weeks post-surgery, using a walking track apparatus and a numerical camcorder. At the end of this period, motor and sensitive responses of the regenerated axons were calculated and histological analysis was performed. We observed that vitamin D2 significantly (i) increased axogenesis and axon diameter; (ii) improved the responses of sensory neurons to metabolites such as KCl and lactic acid; and (iii) induced a fast-to-slow fiber type transition of the Tibialis anterior muscle. In addition, functional recovery was not impaired by vitamin D supplementation. Altogether, these data indicate that vitamin D potentiates axon regeneration. Pharmacological studies with various concentrations of the two forms of vitamin D (ergocalciferol vs. cholecalciferol) are now required before recommending this molecule as a potential supplemental therapeutic approach following nerve injury.

I don't understand why I can open the link and others cannot.

Doses are not discussed for humans. It remains a good idea to get tested to see where you stand. If you self medicate you may take too little to see benefit.
But many people that post on boards with chronic pain issues are seeing low levels come back from testing, and improvement with D3 supplements. (D2 is less effective)

nide44 · 11-10-2008, 09:32 AM

I can't open it either
It takes me to
http://www.liebertonline.com/cookieabsent.html

& It gives me this message (direct cut & paste)

An Error Occurred Setting Your User Cookie

and a whole page of nebulous cookie info.

mrsD · 11-10-2008, 10:04 AM

I don't get it. And I don't have any hits on my 3 scans I do weekly either.

Here is the paper on PubMed...looks like what I quoted above.

Quote:

J Neurotrauma. 2008 Oct;25(10):1247-1256.Click here to read Links
Vitamin D(2) Potentiates Axon Regeneration.
Chabas JF, Alluin O, Rao G, Garcia S, Lavaut MN, Risso JJ, Legre R, Magalon G, Khrestchatisky M, Marqueste T, Decherchi P, Feron F.

Neurobiologie des Interactions Cellulaires et Neurophysiopathologie (CNRS UMR 6184), Université de la Méditerranée (Aix-Marseille II), Faculté de Médecine Nord, Institut Fédératif de Recherche Jean Roche (IFR11), Marseille, France., Services de Chirurgie de la Main, Chirurgie Plastique et Réparatrice des Membres, Assistance Publique, Hopitaux de Marseille, Marseille, France.

Abstract To date, the use of autograft tissue remains the "gold standard" technique for repairing transected peripheral nerves. However, the recovery is suboptimal, and neuroactive molecules are required. In the current study, we focused our attention on vitamin D, an FDA-approved molecule whose neuroprotective and neurotrophic actions are increasingly recognized. We assessed the therapeutic potential of ergocalciferol-the plant-derived form of vitamin D, named vitamin D(2)-in a rat model of peripheral nerve injury and repair. The left peroneal nerve was cut out on a length of 10 mm and immediately autografted in an inverted position. After surgery, animals were treated with ergocalciferol (100 IU/kg/day) and compared to untreated animals. Functional recovery of hindlimb was measured weekly, during 10 weeks post-surgery, using a walking track apparatus and a numerical camcorder. At the end of this period, motor and sensitive responses of the regenerated axons were calculated and histological analysis was performed. We observed that vitamin D(2) significantly (i) increased axogenesis and axon diameter; (ii) improved the responses of sensory neurons to metabolites such as KCl and lactic acid; and (iii) induced a fast-to-slow fiber type transition of the Tibialis anterior muscle. In addition, functional recovery was not impaired by vitamin D supplementation. Altogether, these data indicate that vitamin D potentiates axon regeneration. Pharmacological studies with various concentrations of the two forms of vitamin D (ergocalciferol vs. cholecalciferol) are now required before recommending this molecule as a potential supplemental therapeutic approach following nerve injury.

PMID: 18986226 [PubMed - as supplied by publisher]

Related Articles

* Functional recovery after peripheral nerve injury and implantation of a collagen guide. [Biomaterials. 2008]
* Metabosensitive afferent fiber responses after peripheral nerve injury and transplantation of an acellular muscle graft in association with schwann cells. [J Neurotrauma. 2006]
* A collagen-based nerve guide conduit for peripheral nerve repair: an electrophysiological study of nerve regeneration in rodents and nonhuman primates. [J Comp Neurol. 1991]
* ReviewTransplants and neurotrophic factors increase regeneration and recovery of function after spinal cord injury. [Prog Brain Res. 2002]
* ReviewEffectiveness and safety of vitamin D in relation to bone health. [Evid Rep Technol Assess (Full Rep). 2007]

Most of the paper is all about pipettes and lab protocols etc, and how the study was run actually. The only other part was the mention of only using D2 (because that is what doctors are familiar with).

Try this:
I went to the site and removed part of the url---

http://www.liebertonline.com/doi/pdf...neu.2008.0593?
This also works for me and has the "cookie" bit removed.

dahlek · 11-10-2008, 10:49 AM

That last link was the charm! Thanks! - j

echoes long ago · 11-10-2008, 12:28 PM

that last one works for me now also.

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