Looking for articles linking B12 deficiency and Nitrous Oxide

mrsD · 03-14-2009, 09:23 AM

1 to 2 % of an oral dose of B12 is passively absorbed in the small intestine. So if you take 1000mcg you get maybe 10-20 mcg.

If you take 5mg orally you can possibly get 50-100 mcg that way.
The RDA if you ate food and could break it out of food properly
is 2.4 mcg a day for adults.

Sublingual absorption has not shown up in studies as very useful.

Many doctors do not know about this study however:

Quote:

Clin Lab Haematol. 2003 Jun;25(3):161-6.Click here to read Links
Efficacy of short-term oral cobalamin therapy for the treatment of cobalamin deficiencies related to food-cobalamin malabsorption: a study of 30 patients.
Andrès E, Kaltenbach G, Noel E, Noblet-**** M, Perrin AE, Vogel T, Schlienger JL, Berthel M, Blicklé JF.

Department of Internal Medicine, Diabetes and Metabolic Disorders, Hôpitaux Universitaires de Strasbourg, France. emmanuel.andres@chru-strasbourg.fr

BACKGROUND: It has been suggested that oral cobalamin (vitamin (B12)) therapy may be an effective therapy for treating cobalamin deficiencies related to food-cobalamin malabsorption. However, the duration of this treatment was not determined. PATIENTS AND METHOD: In an open-label, nonplacebo study, we studied 30 patients with established cobalamin deficiency related to food-cobalamin malabsorption, who received between 250 and 1000 microg of oral crystalline cyanocobalamin per day for at least 1 month. ENDPOINTS: Blood counts, serum cobalamin and homocysteine levels were determined at baseline and during the first month of treatment. RESULTS: During the first month of treatment, 87% of the patients normalized their serum cobalamin levels; 100% increased their serum cobalamin levels (mean increase, +167 pg/dl; P < 0.001 compared with baseline); 100% had evidence of medullary regeneration; 100% corrected their initial macrocytosis; and 54% corrected their anemia. All patients had increased hemoglobin levels (mean increase, +0.6 g/dl) and reticulocyte counts (mean increase, +35 x 10(6)/l) and decreased erythrocyte cell volume (mean decrease, 3 fl; all P < 0.05). CONCLUSION: Our findings suggest that crystalline cyanocobalamin, 250-1000 microg/day, given orally for 1 month, may be an effective treatment for cobalamin deficiencies not related to pernicious anemia.

PMID: 12755792 [PubMed - indexed for MEDLINE]

from http://www.ncbi.nlm.nih.gov/pubmed/12755792?ordinalpos=1&itool=EntrezSystem2.PEntrez. Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.P ubmed_Discovery_RA&linkpos=4&log$=relatedarticles& logdbfrom=pubmed

We have seen posters here who did not respond quickly to 1000mcg (1mg) doses as in this study. So that is why I recommend 5mg to start. I think if people have depleted the liver, some of the supplement goes there partially, so blood levels may not come up as quickly because of that priority.

Whatever works for you, do it! You are right, everyone is different!

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