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Old 01-05-2012, 07:29 AM #41
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Quote:
Originally Posted by mrsD View Post
I really do think damaged mitochondria are at the heart of many forms of PN.
I think you are right and the reason is:

"Muscle and nerve cells are big users of ATP. Nerve cells consume large amounts of glucose, which they use for production of ATP by aerobic respiration.

. . .

"In nerves, ATP is used mostly for active transport of sodium (Na+) and potassium (K+) ions but also drives secretion of neurotransmitter chemicals by the endomembrane system."

http://www.uwyo.edu/bio1000skh/lecture17.htm

I always wondered why my nerves didn't do their job properly when I was exhausted.

I wish I could see some research on exactly how much ATP nerves actually use.

---

Before I forget, here's something interesting on mitochondria:

"The long-term presence of excess cytokines is very damaging, and many scientific antennae are now tuned into cytokines as the factor which prevents mitochondria from repairing themselves. Major stimulants of excess cytokine production certainly include viruses and other infections, but once the infection has healed, cytokine production should cease. In M.E., arthritis and other chronic diseases for some reason it appears that it does not."

So before anyone spends a lot of money on mito support products, it may be worth getting a blood test first, esp. if anyone with CFS, or those who can't afford a slow recovery.

---

On a list of things Mg does, in a previous thread (on PD):

Quote:
Magnesium activates almost all the key enzymes needed for your neurons to produce energy from glucose, in the form of ATP molecules. Magnesium is also necessary for the stable storage of ATP, so it won't spontaneously break down and waste its energy as heat.
I wonder if this could explain the common problem of those with peripheral neuropathy, i.e., getting too hot, and failure to sweat.

Say the ATP breaks down as heat. Then it breaks down further, lacking the energy to complete the process of sweating to remove the heat, i.e., back-to-back failures.

I have a chronic problem of skin heating up where nerve damage apparently was done.

I don't see how the heat could be there, esp. as high as the temp gets, unless there's a lot of energy involved. It could also explain chronic fatigue, i.e., the conversion of ATP is chronically impaired, like an energy 'parasite.'

Last edited by NeuroLogic; 01-05-2012 at 11:54 AM.
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Old 01-23-2012, 05:03 PM #42
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Lightbulb Minding your Mitochondria ~Video:

The PD forum has this, and now the MS forum posted it.

I thought to bump this thread for us too:

http://www.wimp.com/mindingmitochondria/
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Old 01-24-2012, 01:31 AM #43
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^^That's an amazing video. Wow.

I don't know how anybody eats (or can afford) that much food every day, but I guess I'm going to try and find out.

P.S. Who's got good kale recipes here?
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Old 01-24-2012, 07:15 AM #44
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Lightbulb

The only comment I have... is that for people with intolerances, it might be difficult.

I cannot do cabbage... haven't been able for YEARS.
But I have that twisted GI tract from birth, which is pretty rare, that others don't. For those who cannot digest this much veggies I suggest BEANO. I use it now when I have lots of gas producing veggies. (but I still cannot tolerate cabbage). Lots of cabbage and its relatives may also suppress thyroid functions.
http://www.marysherbs.com/Miscellane...egetablesP.htm
One can obtain lots of sulfur from eggs. And nuts:
http://healthyeatingclub.com/info/bo...ta/data5g.html
If you look at this chart you'll see sulfur can be had from many other foods in larger amounts that in the veggies she listed.
Here is iodine:
http://healthyeatingclub.com/info/bo...ta/data5k.html

Also something to consider: When you eat alot of vegetables, there are phytates in them that complex out zinc. Vegans therefore are at risk for becoming zinc deficient if they are not careful.

I also cannot do nightshades, esp the peppers. I can avoid potatoes without much difficulty.

I do see she eliminated gluten, and dairy...both are huge triggers in leaky gut, and could have been the real cause of her issues basically.

It was interesting seeing her chart on nutrients that are commonly low in the US.

Doctors go thru intense training, in school and in their internship/residencies. No time for quality food intake or eating and sleeping. This alone could have triggered her MS.

I see her recommendations as useful, but perhaps not 100% applicable by everyone equally.
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Old 01-24-2012, 02:53 PM #45
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I have the Minding my Mitochondria books as well as other good books. I am paying close attention to Gycation. Terrible for nerves/body. Not just for people with high blood sugar problems. I have never had that.

I am responding so well to Alpha Lipoic Acid (Slow release ALA MAX by Xymogen) and Benfotiamine (Fat/water soluble B1) that my integrative MD told me to really be careful about sugar and look into a book by Dr. Steven Gundry so I have that as well as others.

I take a lot of supplements for CFS and POTS (Postural Orthostatic Tachy. Syndrome from Autonomic Neuropathy) and supporting mitochondria is so important for those problems. D Ribose, Carniclear, Alpha Lipoic Acid, Co Q10, ATP etc as well as well as healthful food is important. There is so much we can do to safely heal.
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Old 01-24-2012, 03:00 PM #46
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R-lipoic stablized is far better than old ALA.... you might want to try it. Far more absorbed, and faster onset with much less expense and milligrams. It is new... some manufacturers have not caught up with it yet. Doctor's Best brand is the most affordable with quality, and many of us use it now.

It is wonderful you are seeing results, Sally. I think our mitochondria take many hits from our environment and antibiotic use. ( and who knows what else!)
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Old 01-24-2012, 03:35 PM #47
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That is what is thought sometimes but what I take is the best. My integrative doctors are on top of all of the studies and brands etc. Thank goodness.
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Old 01-24-2012, 05:38 PM #48
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I think quote sums up my problem:

“Increased oxidative damage from diminished mitochondrial function has been shown to trigger inflammation and launch protein-destroying enzymes into action.” -LEF

http://www.lef.org/magazine/mag2010/...-Damage_02.htm

My heat problems are local but progressive and always follow low-ATP-related stress, esp. after sleep disruption.
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Old 01-24-2012, 06:11 PM #49
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I am a member of LEF. Such great information. On the page above, they also talk about Benfotiamine. That is one of my favorites up there with Alpha Lipoic Acid for nerve health.
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Old 01-25-2012, 05:23 AM #50
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Lightbulb

I agree about the Benfotiamine. I use 150mg a day. It has been useful for me too.

LEF also is now newly offering stablized R-lipoic acid:
they call theirs "super".

http://www.lef.org/Vitamins-Suppleme...poic-Acid.html
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