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Amitriptyline only antidepressant that really works on PN?

 
 
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Old 06-26-2009, 10:45 AM #1
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Lightbulb Amitriptyline only antidepressant that really works on PN?
Some new information on why Amitriptyline works:

http://psychcentral.com/news/2009/06...tors/6761.html

Quote:
Doctors also prescribe amitriptyline for chronic pain such as migraine headaches or the nerve damage caused by diabetes, he notes.

In laboratory tests, amitriptyline could protect neurons from oxygen and glucose deprivation or the toxin kainic acid. Only amitriptyline, and not other antidepressants, could duplicate NGF’s ability to stimulate neurons to send out “neurites,” small projections thought to be the beginnings of connections to other neurons.

Amitriptyline directly binds TrkA and a related molecule called TrkB, the authors found. Amitriptyline could also bring together a mismatched pair of TrkA and TrkB — a phenomenon not seen before, Ye says.

Also surprising was the finding that other tricyclic antidepressants — even those with a similar molecular structure such as imipramine — could not match amitriptyline’s ability to stimulate cells through TrkA.

In a model of antidepressant function called a “forced swim test,” amitriptyline’s effects do not depend on TrkA, because it still works on mice with modified TrkA genes, the authors found.

The results are published online and appear in the June 26 issue of the journal Chemistry & Biology.
So it looks here like Elavil (amitriptyline) is the drug of choice now.
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