Hi. Per my pain dr. at USC, the FDA has yet to approve ANY potentiated opioid meds, except for a couple of combo pills used in opioid withdrawl, but the % compositions are not what you would want for maximum analgesia, even though it's possible to run narrowly tailored PubMed searches and pull up over 2,000 possible hits. Obviously people are working very hard in this area, but outside of the studies, the only parients who have apparently benefited thus far are those with pumps, where their doctors have quite a bit of freedom in adjusting the exact mix of the broth in which they are then stewed.

As far has Botox in blocks are concerned, I can't recall hearing anything offhand (which desn't mean much) but would be concerned by one issue in particular: what happens if the toxin inadvertantly enters an organ or tissue that you don't want to put into suspended animation for 4 months or so? E.g., liver, heart, etc. Potentially very bad news.

Mike