Hi Mike,

Remember this one?


Beyond Neurons: Evidence That Immune and Glial Cells Contribute to Pathological Pain States

http://physrev.physiology.org/cgi/content/full/82/4/981

Peripheral nerves are the origin of almost all forms of neuropathic pain. This section is divided into two major subsections. Section IIA provides an overview of peripheral nerve anatomy and immunology, by addressing issues of 1) anatomy and immune surveillance, as well as nerve damage caused by 2) antibodies, 3) complement, 4) T lymphocytes, and 5) trauma. The purpose is to provide the background for the clinically relevant discussion that follows. Section IIB focuses on painful neuropathies that involve nerve trauma and/or inflammation. Within this, three clinical neuropathic pain syndromes are examined: 1) complex regional pain syndromes associated with peripheral nerve trauma and/or inflammation, 2) autoimmune neuropathies, and 3) vasculitic neuropathies. For each, an examination of the clinical findings is first discussed followed by a summary of data from relevant animal models. The argument to be developed is that immune attack of peripheral nerves, or even simply immune activation near peripheral nerves, is sufficient to create increases in peripheral nerve hyperexcitability and/or damage so as to be considered a significant contributor to the neuropathic pain observed.

Roz -

That was for a good while the lone voice in the wilderness, at least as far as we knew. Txs.

xxx
Mike

ps Although I'll admit I didn't understand a lot of it at the time.

Dear Mike,

In school, cell biology was not my thing, but I excelled in Art.

It was this article that led me to study about proinflammatory cytokines and T Cells.

The T cell's not balancing right is really a fright to me.

Which led me to my immune system not being protected, so I wondered what got in their in my case. In other words why am I so weak, and my immune system at ground level.

So I starting asking questions to MD's if it was possiable if something invaded my immune system and could effect the nerves as well.

cont..

As far as understanding goes, they make alot of these medical journals very difficult to comprehend, they certainly do not use the KISS method.

You know how I feel about THINGS entering the BBB in my case, in my opinon they require treatment. But 99.9% of MD's will not even have a clue.

Like for instance, cell to cell signaling plays a huge role as well. If you do some resarch on that one, it's like the article's are in French.

Much Love, Roz

PS. Help me with spelling bud.

I am a firm believer that the immune system plays a role in RSD. I personally believe that my immune system was taxed before my surgery for a number of reasons, and therefore my immune system wasn't able to deal with surgery effectively. This may seem like a stretch, but I've been looking at the similarities with Autism (although obviously the symptomology is different, both are neurological). There are a lot of people with autism that have an improvement in symptoms after doing things to clean up their immune systems detoxing, changing diet getting rid of yeast, gluten, casien, cleaning up their gut--getting rid of bad bacteria and introducing the "good" and even getting rid of parasites, going organic so it's one less thing for the immune system to deal with (processing pesticides), taking different supplements. If this can help with a neurological problem like autism (which was thought to be "incurable," than why not RSD, if it really is related to an immune problem? I actually did try quite a bit of this, as I was reading "Mother Warriors" as I was going through HBOT. I'm not sure how much it played a role in my improvement compared to everything else I've tried, but I AM better now. I haven't stuck with the diet, though, after I began to feel better.

Hi Miller,

I love your spirit and atitude.

Much Love, Roz xoxo

Hey Mate,

I have been doing a little research on the Parvo. I won't hold the Mayo this time.

http://www.ncbi.nlm.nih.gov/pubmed/7861814

To Millerprof -

Hi. I can't find where I first saw it, but a few years back I came across an article that suggested that when folks were already under high stress - that is carrying a heavy load of C-reactive proteins, among other things - they were at greater risk of getting CRPS from injuries, analogously to how they would be more likely to develop recurrent colds and other minor infections. That said, the research on autoimmunity takes this one step farther, to one of a number of mechanisms whereby CRPS may actually be maintained in the body.

And anecdotally, a number of women of this and the old BT forum have reported that their CRPS went into remission during pregnancy, which is consistant with research showing that the body changes it's immune reponse during pegnancy so as to avoid attacking the fetus as a hostile "other." As an example of the general concept, take a look at:

"Autoimmune disease during pregnancy and the microchimerism legacy of pregnancy," Adams Waldorf KM, Nelson JL, Immunol Invest. 2008; 37(5): 631-44.

Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. adamsk@u.washington.edu

Pregnancy has both short-term effects and long-term consequences on the maternal immune system. For women who have an autoimmune disease and subsequently become pregnant, pregnancy can induce amelioration of the mother's disease, such as in rheumatoid arthritis, while exacerbating or having no effect on other autoimmune diseases like systemic lupus erythematosus. That pregnancy also leaves a long-term legacy has recently become apparent by the discovery that bi-directional cell trafficking results in persistence of fetal cells in the mother and of maternal cells in her offspring for decades after birth. The long-term persistence of a small number of cells (or DNA) from a genetically disparate individual is referred to as microchimerism. While microchimerism is common in healthy individuals and is likely to have health benefits, microchimerism has been implicated in some autoimmune diseases such as systemic sclerosis. In this paper, we will first discuss short-term effects of pregnancy on women with autoimmune disease. Pregnancy-associated changes will be reviewed for selected autoimmune diseases including rheumatoid arthritis, systemic lupus erythematosus and autoimmune thyroid disease. The pregnancy-induced amelioration of rheumatoid arthritis presents a window of opportunity for insights into both immunological mechanisms of fetal-maternal tolerance and pathogenic mechanisms in autoimmunity. A mechanistic hypothesis for the pregnancy-induced amelioration of rheumatoid arthritis will be described. We will then discuss the legacy of maternal-fetal cell transfer from the perspective of autoimmune diseases. Fetal and maternal microchimerism will be reviewed with a focus on systemic sclerosis (scleroderma), autoimmune thyroid disease, neonatal lupus and type I diabetes mellitus.

PMID: 18716941 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum

That said, I am also a firm believer that reversable changes in the brain itself play a significant role in the maintenance of CRPS, a view the is supported by the success of a number of treatments including mirror imaging therapy, high dose NDMA-receptor antagonists (ketamine) and even - I would still dare to submit - RUL ECT.

Mike

[QUOTE=fmichael;501786]To Millerprof -


And anecdotally, a number of women of this and the old BT forum have reported that their CRPS went into remission during pregnancy, which is consistant with research showing that the body changes it's immune reponse during pegnancy so as to avoid attacking the fetus as a hostile "other."



so you think that the women that went into remission that their immune system changed with pregnancy. then my question is what would be the difference for me since with both of my pregnancy my rsd DIDNT go into remission and after the csection my rsd spread internally and got worse after each child? as i havent found any research on RSD and pregnancy that is even worth the read

carrie

It's interesting that you mention autism since I have a little asperger's in all probability. The last neurologist I asked about this condition asked me to spell it for him.

This is a very interesting thread. I skimmed it too much the first time through.