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slept 30 hours. not on any new meds..didn't take xanax or ambien

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Old 08-02-2014, 08:11 PM #21
Mark in Idaho Mark in Idaho is offline
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If they are measuring plasma concentrations, the more plasma in a body, the lower the concentration for the same dose. Blood volume is directly proportional to weight.

All this data aside, what matters is how the person reacts to a specific dose of gabapentin. All the theory in the world will not over-rule how an individual responds.

If plasma concentration peaks at 3 hours, I must be responding to a lower concentration. Maybe the higher concentration achieved later is what helps me sleep so soundly.
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Old 08-03-2014, 12:59 AM #22
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Originally Posted by Mark in Idaho View Post
If they are measuring plasma concentrations, the more plasma in a body, the lower the concentration for the same dose. Blood volume is directly proportional to weight.
That sounds right when you're considering the difference between a child and and adult, or even between a 5.3 woman and a 7.2 man, say.

However, if considering two adults of about the same height and build, where one is skinny and one is rotund, I don't see it.

Are you saying that if I, who weigh 140lb, were to put on another 140lbs, my plasma volume would double?

[edited to add that I sort of answered my own question in the next post.]

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All this data aside, what matters is how the person reacts to a specific dose of gabapentin. All the theory in the world will not over-rule how an individual responds.
Right, and not only, the data itself shows that response to this particular drug is highly individual -- response doesn't correlate to plasma concentration.
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If plasma concentration peaks at 3 hours, I must be responding to a lower concentration. Maybe the higher concentration achieved later is what helps me sleep so soundly.
Remember that 3 hours is the statistical mean. You might peak sooenr, and I might peak later.
Also remember that we can feel effects sooner than peak -- might be your case.

The helping to sleep is really individual. What helps whom depends a lot on why one is having difficulty sleeping. When I go to a sleep aid it's because I basically need a boulder dropped on my head.

take care

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Last edited by waves; 08-03-2014 at 01:27 AM.
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Old 08-03-2014, 01:26 AM #23
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However, if considering two adults of about the same height and build, where one is skinny and one is rotund, I don't see it.

Are you saying that if I, who weigh 140lb, were to put on another 140lbs, my plasma volume would double?
I'm guessing there would have to be a constant so it wouldn't increase by the same proportion as weight, but still in a linear fashion. I found an interesting article that brings up *all kinds* of considerations in the case of obese patients... not just blood volume. Apparently med absorption can increase or decrease depending on the specific characteristics of the med.... I am not going to hazard a guess with gapapentin, lol:

http://www.healio.com/orthopedics/jo...ons-in-obesity

(The article discusses mostly drugs associated with orthopedic surgery, but it talks about the whys and the wherefores... and these are quite interesting, and diverse! )

Happy reading to anyone interested.
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Old 08-04-2014, 05:50 PM #24
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just fantasizing here, but wouldn't it be great if we could just check ourselves into a swanky hospital, some sorta drug would knock us out and another drug would fix our brain. then we'd wake up with no memory of the horrors of pcs, but we would still be able to walk away with the wisdom gained. or not. f' wisdom.
Yeah I keep thinking about this as well. If they could just put me in a coma for 6 months to let my brain rest, I wouldn't mind that at all. You go to sleep, and wake up all good 6 months later.
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12/02/2012 - Light concussion at boxing practice. Ended up having PCS for about 3 months.
March 2013 - Thought that since most of my symptoms resolved I could start having fun again.
Went snowmobiling once (didn't hit my head) and concussion symptoms returned and got even worse than before.
June 2013 - accidentally bumped my head against a deck railing, and had a month-long setback.
November 2013 - drove to work after a big snowstorm and the roads were very rough, ended up having another setback.
2014 - Having setbacks after coughing/sneezing too much, or someone slapping me on the back, or any other significant jarring.
Feb 2014 - Started seeing Atlas Orthogonal chiro - most helpful doc so far.
June 2014 - Two months of physical/visual therapy - no noticeable improvement.
September 2014 - Diagnosed with Perilymph Fistula in right ear.
November 2014 - Fistula surgery (switched to left ear before the surgery after additional testing).
January 2016 - Quit work to "work" on figuring out PCS, so far it seems that eyes/vision issues are the most contributing factor, especially computer work.

Current symptoms are: inconsistent sleep patterns, headaches, vertigo/dizziness, anxiety/panic attacks, mental fog/problems with concentration, problems with computer screens.
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