Hello everyone. My b12 was low so I starting taking Methyl b12 . Every time I take it I get the following symptoms; depression, very irritable, hopeless and depressed, and I don't know how to exactly to explain this, but a general feeling of 'heaviness,' as if gravity is pulling on me twice as hard (weird I know).

The higher the dose, the quicker the symptoms will appear and the more severe.

I have only read of a handful of others reacting this way to Methyl b12 but I have yet to hear an explanation as to what is going on.

I do not have this issue when taking cynacobalamin, even with large doses.

I am not taking any other medications or herbs.

I would greatly appreciate any help on solving this riddle as well as some good advice.

Thanks,

Shane

Hi
you may be genetically an "over methylator"?

I am not up on the latest research on this but think that people who over methylate need to avoid methyl donor supplements eg the methyl B12 where good for others may be a problem for people who over methylate. There is also a lot of new info out on mthfr gene mutation and methylation

Hopefully someone who knows more about this can give you more relevant info.

For now though, it may be wise to stop using the methyl B12 and stick with cyano-

Thanks Chemar for your reply. So, I guess if I may be a "over methylator," then there is a good chance that I may get the adequate amount of b12 from cyno?

Thanks,
Shane

Not necessarily Shane as I think it is not as "bioavailable" that way. So you may need more? but again, this is something someone with more knowledge than I have would be best advising on.

However, if you are an over methylator, then as far as I know, you should avoid any methylated supps.

Thanks Chemar. Are there many other supplements that are methylated that I should be aware of?

Thanks,
Shane

There is a pretty common genetic error in methylation of
both cobalamin and folic acid 10 to 30% cannot do this.
It is tested for with a DNA test---23andme online does this
For 99 dollars... No doctor required.

Did you have any blood work done to see if you need more
B12?

What were the results if you did?

I am on an iPhone so linking is difficult for me now.

But our PN forum on the first 2 pages has two threads by
Muiriann on methylation (MTHFR) and Suzy Cohen's
Blog explaining more. My B12 thread in the stickies on
page one there has all you need to know about B12.

I won't be home until after LaborDay.

I am so glad to hear from you Mrs. D! I have read several of your posts and was hoping that you'd chime in.

B12 was a little under 200 if I remember right, and this was about 3 months ago.

I know that you may not be able to respond for a while but do you think I should just continue with a b12 complex? I have been doubling up on the dose so that would be about 2000mcg of cyano b12.

I absolutely cannot take methyl b12; it turns me into a roid-like-rage-monster!

Thank you so much for your time in replying to my questions.

Shane

Shane...mrsD may have more details when next she checks in...but if you mean doubling up on a B Complex (ie a supplement that has all the B vitamins) I don't think that is a good idea as not all the Bs are beneficial in mega doses. Some people just seem very sensitive to some of the other Bs so taking above the RDA may not be wise unless you are deficient in them

If you mean by "B12 complex" that is is just a B12 supp...that is different as yes, B12 can be taken at higher doses.

I am new to this site so you may need alot of patience. I am desperate for someone to give me guidance because I am not getting anywhere with GP who I really love but for some reason we're missing mark. Last year, aug 2012, i decided to do bloodwork myself because all i kept getting was i'm stressed. The b12 came back 347. My folate was 11. My iron was low. My vit d was low. Went back to the doctor and put on presciption vit d and said to take b12. Got methyl b12 at gnc. starting feeling better. Then got an attack in march 2013Weak. I had not taken the vitamins in 3 weeks. Headache bad. Fainting. severe confusion. on and on. Went to hospital for ms. Negative. For stroke. Negative. Said could find nothing. Went back on b12 sublingually. Felt better. Not back to normal. Just had another attack about 10 days ago. Severe neuropathy. anxiety. extremely soar muscles. Burning. on and on. Cold hands alternating with swollen hands. Dr said it was pernicious anemia. went on B12 injections of methly b12 from *admin edit* because doctor would not prescribed. Felt good yesterday. (better i mean). feeling crappy again today and last nite. Couldn't sleep. Took melatonin. Nope. took quarter of ambien. Nope. Took a clonopin. Slept to 5 hours. Woke up to same thing. slight headache. Forgot to say, went to GNC for methly-folate acid. Took one yesterday and day before. Tested postive for MTHTR (?). have the C677 one. Hetergenous. Am I missing something to get rid of this? I am so frustrated. I hate feeling this way. I think it's a b12 deficiency. could it be something else and I can I get better. If you can give me any suggestions I would be so grateful. I made an appointment with a kineologist this week. I just don't want to take anymore medicine. I take zoloft for the past 17 years and clonopin as needed for anxiety. Which is usually only a couple days a month. Last night I had alot of anxiety. Thank you so much for even listening. Sincerely, Kathleen
age 50. female. if you need to know that.

--most prominently celiac disease?

Many of the symptoms you describe could be from lack of essential nutrients, but if that's the case some thing is likely underlying the inability to absorb or take those in.