[bruegger84]

came upon some information and didn't really understand what it meant?:

coenzyme Q10 shares a common biosynthetic pathway with cholesterol. The synthesis of an intermediary precursor of Coenzyme Q10, mevalonate, is inhibited by some beta blockers, blood pressure-lowering medication,[20] and statins, a class of cholesterol-lowering drugs.[21] Statins can reduce serum levels of coenzyme Q10 by up to 40%.[22] Some research suggests the logical option of supplementation with coenzyme Q10 as a routine adjunct to any treatment that may reduce endogenous production of coenzyme Q10, based on a balance of likely benefit against very small risk.

does this mean that coq10 affects efficacy of beta blockers, or beta blockers affects absorption of coq10?

[mrsD]

Originally Posted by bruegger84

came upon some information and didn't really understand what it meant?:

coenzyme Q10 shares a common biosynthetic pathway with cholesterol. The synthesis of an intermediary precursor of Coenzyme Q10, mevalonate, is inhibited by some beta blockers, blood pressure-lowering medication,[20] and statins, a class of cholesterol-lowering drugs.[21] Statins can reduce serum levels of coenzyme Q10 by up to 40%.[22] Some research suggests the logical option of supplementation with coenzyme Q10 as a routine adjunct to any treatment that may reduce endogenous production of coenzyme Q10, based on a balance of likely benefit against very small risk.

does this mean that coq10 affects efficacy of beta blockers, or beta blockers affects absorption of coq10?

It means that the beta blockers prevent your liver from making CoQ-10. Your body makes most of what you need.(We do not get it much from food).
Their effect is much less than the statins.
CoQ-10 does not affect beta blockers that I know of.
CoQ-10 is involved in the functions of the mitochondria in the cells of muscles. These cells provide energy for muscle contraction. Low levels of CoQ-10 may cause heart failure over time.

[judymoody]

I don't want to hijack your post Bruegger, but I have a question about this as well, and you all have the experience and knowledge . . . does CoQ10 need to be taken in conjunction with Acetyl Carnitine, Vit C. and a food source containing fats in order for best absorption? I, too, am trying to discover how best to use supplements . . . and what works for me.

[Peter B]

My Daughter takes COQ10 for her ME and has found it to be very beneficial.
She says that you do need a bit of fat with the meal when you take the COQ10.
She also says that you must use the Ubiquinol version, not the Ubiquinone one.

[bruegger84]

Originally Posted by Peter B

My Daughter takes COQ10 for her ME and has found it to be very beneficial.
She says that you do need a bit of fat with the meal when you take the COQ10.
She also says that you must use the Ubiquinol version, not the Ubiquinone one.

I assumed jarrow would contain the most absorbable one, but they don't they use ubiquinone, but they market it under q-absorb, supposedly a higher absorbability version.

[mrsD]

The ubiquinol version mentioned by PeterB is a new form.

It is "activated" and much less/milligram is needed.
It also costs much more money.

For someone critically in need, the specs are different than for others.

[Jaspar]

I beg to differ that the Ubiquinol version is "necessary". Better, perhaps, but not necessarily, necessary A family member with severe, complex pediatric-onset migraines (often associated with need for CoQ10) was put on a very absorbable ubiquinone from www.lef.org -- and it worked extremely well.

The family looked into ubiquinol after it hit the market, but failing to find a brand without soy, which the person is allergic to (there may now be one... anyone know of a brand without soy?), and seeing that what the person was on worked, just kept her on the "super absorbable ubiquinone."

[armac]

[QUOTE=Jaspar;452702]I beg to differ that the Ubiquinol version is "necessary". Better, perhaps, but not necessarily, necessary A family member with severe, complex pediatric-onset migraines (often associated with need for CoQ10) was put on a very absorbable ubiquinone from www.lef.org -- and it worked extremely well.

The family looked into ubiquinol after it hit the market, but failing to find a brand without soy, which the person is allergic to (there may now be one... anyone know of a brand without soy?), and seeing that what the person was on worked, just kept her on the "super absorbable ubiquinone."[/Q

Ubiquinone/Ubiquinol effectiveness...could you tell me what Brand the "Super Absorbable" UBIQUINONE is, please....I would like to try the more effective UBIQUINOL but am put off it at the moment because most of it is in "Softgels" GELATIN, which seems to be mostly manufactured from Animal remains....though, it can be made from non-animal sources..... Have'nt come across UBIQUINOL in SOY so far, while looking online

Trying to put together A PN Supplement-collection for self Treatment.... looking through "iHerb" Products, mostly cheaper than the UK (what is'nt!?)......THEY HAVE QUITE A LOT OF UBIQUINOL PRODUCTS and if you have'nt done so already, might be worth checking out,...seem to be mostly in Softgels......

[armac]

Originally Posted by Jaspar

I beg to differ that the Ubiquinol version is "necessary". Better, perhaps, but not necessarily, necessary A family member with severe, complex pediatric-onset migraines (often associated with need for CoQ10) was put on a very absorbable ubiquinone from www.lef.org -- and it worked extremely well.

The family looked into ubiquinol after it hit the market, but failing to find a brand without soy, which the person is allergic to (there may now be one... anyone know of a brand without soy?), and seeing that what the person was on worked, just kept her on the "super absorbable ubiquinone."

Hi....just found this UBIQUINOL on "iHerb's" Site.....
NOW FOODS (Brand) 100mg..60 Softgels...PRODUCT CODE-NOW-03142
LONG LIST of....Contains no's....seems to include that it Contains no SOY...

[Jaspar]

could you tell me what Brand the "Super Absorbable" UBIQUINONE is, please....I would like to try the more effective UBIQUINOL but am put off it at the moment because most of it is in "Softgels" GELATIN, which seems to be mostly manufactured from Animal remains....though, it can be made from non-animal sources..... Have'nt come across UBIQUINOL in SOY so far, while looking online

Here is a post with lists of some hypoallergenic products including 2 brands of hypoallergenic ubiquinone, one of which is the super-absorbable:
http://itsnotmental.blogspot.com/200...ly-needed.html

Just 50mg works for her, whereas I have heard it can take hundreds of mg of some cheaper brands.