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I am putting myself on Zoloft

 
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Old 07-26-2010, 05:39 PM #11
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Thanks for all the info !

YEah, I know... It's like when my Celecoxib helped with pain but was going to induce me a cardiac attack... Hell...

Mari, that thing about Calcium and depression sounds VERY interesting...
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Old 07-26-2010, 06:58 PM #12
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Default SSRIs and Osteoporosis / bone health
i cannot find it. i ran into it ages ago quite by accident. it has something to do with interfering with osteoblasts more or less than osteoclasts and they get out of balance.

i can't remember if it was even online. maybe it was in some of the stuff i got from my pdoc. (i asked him if he had any medical-stuff he didn't want that he could give me rather than recycle it.) there was a book on women's mental health that discussed all kinds of things related to drugs too, right down to the bone (haha NO pun intended, i don't know if it was in there... if i can find that i'll check.)

oh here. well this isn't it, and it doesn't say much, but at least you know which tree i'm barking up:

http://www.medpagetoday.com/Psychiatry/Depression/6040

Quote:
One potential explanation for these findings, the investigators said, is that SSRIs bring about a reduction in osteoblast activity or a reduction in coupled osteoclast/osteoblast activity, resulting from serotonin transporter inhibition.
i'm ok with using an SSRI, i just think staying on one all the time is a bad idea even if it does work. especially with my poor vitamin D status.

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Old 07-26-2010, 08:23 PM #13
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Okay is cymbalta, the same way with osteoprosis. Or things like this.

Donna
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Old 07-26-2010, 08:56 PM #14
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Dear Donna

Cymbalta, Effexor and Pristiq are SNRIs (Serotonin and Norepinephrine Reuptake Inhibitors). (for Mari: Wellbutrin a little different affecting the dopamine/norepinephrine system).

so, while the studies i've read have all talked about SSRIs i'd think there would be some theoretical concern with Cymbalta and the other two as well, because they all inhibit serotonin reuptake. i don't know to what degree as compared to SSRIs... and if different receptor subtypes are affected... it is possible that there is inferior or no risk with these drugs.

a long way to say, maybe.

i'll see if i can turn up anything specific for you Donna.



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Last edited by waves; 07-26-2010 at 09:50 PM.
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Old 07-26-2010, 10:01 PM #15
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Wink Donna - Cymbalta / SNRIs
from Psychiatric Times

Bone Mass Density Loss and Antidepressants...
By James M. Ellison, MD, MPH
October 1, 2008

http://www.psychiatrictimes.com/disp.../10168/1336555

Quote:
I could locate no study that addresses serotonin norepinephrine reuptake inhibitor (SNRI) effects on BMD, although the SNRIs’ serotonergic effects certainly raise the possibility of a similar BMD reduction risk.
also - this explains it in a more similar fashion to what i originally read.

CHANGING THE PICTURE IN DEPRESSION... (MS Word document)
Sinan Duzyurek, MD
July 18, 2009

Quote:
Too high intercellular concentrations of serotonin outside the bone cells (e.g., due to lurking SSRI molecules) preferentially stimulate osteoclasts, which degrade bone. Thus, patients on SSRIs and SNRIs are at increased risk for fractures, and women have double the incidence of osteoporosis.
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Old 07-26-2010, 11:32 PM #16
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sounds like a good plan! hOpe you feel much better very soon.
I am sorry that you are feeling rotten.
(((((HUGS))))
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Old 07-26-2010, 11:36 PM #17
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thanks bizi! welcome back!!!

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Old 07-26-2010, 11:43 PM #18
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Even though im young i know that medication may feel like it can help but all it does is numb the mind. Save your family greef , & try something to substiute it ? May i suggest fish oil , it did wonders for my mother who had chronic spine pain & cogested heart failure . I wish nothing but luck ,
Kitty .
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Old 07-26-2010, 11:57 PM #19
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Thank you Kitty!

welcome to Neurotalk!

actually i was going to try 5-HTP but i am pretty broke as far as buying anything at all. as it happens i already have a lot of Zoloft left over from before. and it has typically worked for me in that past. i don't have side effects from it at moderate doses.

i am sorry if you have had bad experiences with meds. some folks have a very difficult relationship with meds/finding something that works.

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Old 07-27-2010, 06:31 PM #20
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Oh oh oh !! Ive always wanted to try 5-HTP, but they dont sell it here alone, or I dont know where !!

Kitty, welcome !! And sorry for contradicting you, maybe Im the exception... but Fish did NOTHING for me...

Hugs for everyone !
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