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Old 05-07-2012, 05:20 AM #5
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Please be careful.

Drugs that affect neurotransmitters in the brain, all have some sort of discontinuance/withdrawal effects.

These are the receptors affected:
Quote:
Ziprasidone exhibited high in vitro binding affinity for the dopamine D2 and D3, the serotonin 5HT2A, 5HT2C, 5HT1A, 5HT1D, and α1-adrenergic receptors (Ki s of 4.8, 7.2, 0.4, 1.3, 3.4, 2, and 10 nM, respectively), and moderate affinity for the histamine H1 receptor (Ki=47 nM). Ziprasidone functioned as an antagonist at the D2, 5HT2A, and 5HT1D receptors, and as an agonist at the 5HT1A receptor. Ziprasidone inhibited synaptic reuptake of serotonin and norepinephrine. No appreciable affinity was exhibited for other receptor/binding sites tested, including the cholinergic muscarinic receptor (IC50 > 1 μM). Antagonism at receptors other than dopamine and 5HT2 with similar receptor affinities may explain some of the other therapeutic and side effects of ziprasidone. Ziprasidone's antagonism of histamine H1 receptors may explain the somnolence observed with this drug. Ziprasidone's antagonism of α1-adrenergic receptors may explain the orthostatic hypotension observed with this drug.
from http://www.rxlist.com/geodon-drug/cl...armacology.htm

So discontinuing this drug would have to be done carefully.
The link to the alpha-1-adrenergic receptors suggests that there may be elevated blood pressure on discontinuance. So I would be sure to monitor that as well.
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