I did end up seeing my pdoc the next day. I was escalating at that point.

She increased my nighttime dose, but she prescribes medication to be taken prn (as needed) during the day because the amount I need varies.
She said this sometimes happens with patients who take Seroquel.

Other patients take small doses (usually 50mg) off-label (accepted and widely used by medical professionals but not approved by FDA) prn for sleep.

Kay

Are you able to get a good nights sleep?
bizi

Most nights I sleep pretty well thanks to the Seroquel, but some nights MS sx act up and I lose a couple of hours.

I am glad that most nights you get good sleep.
bizi

Saturday night: I got very lightheaded and learned the hard way not to take Xanax and 600mg of Seroquel too close together. 700mg for the day.

Sunday: I only needed 650mg to keep me grounded. I was exhausted, but not dull/flat.

I left the house to run errands both days. I only leave the house to go to the grocery store, pharmacy, or doctor so it was a pretty exciting weekend for me

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I've been keeping notes:

A couple of days ago I was dismissing symptoms that might be hypomania at 11am until about 2pm.

Until today I've been blaming all my early morning hypo symptoms on anxiety. That is when my anxiety is at its height, but it usually responds to Xanax. It hasn't been responding to Xanax... and it doesn't seem to become clear to me that I'm hypomanic until hours later. I should know better.

I think it's possible that I was just unwilling to admit to myself that those hypo symptoms are going to be there when I wake up everyday.

I took 50mg when I got up. And I just took 50mg more.

Kay